L-NORADRENALINE BITARTRATE

The Uses of L-NORADRENALINE BITARTRATE

Adrenergic (vasoconstrictor).

brand name

Levophed (Hospira).

Clinical Use

Hypotension
Cardiac arrest (sympathomimetic)

Safety Profile

Poison by intravenous andintraperitoneal routes. When heated to decomposition itemits toxic fumes of NOx.

Drug interactions

Potentially hazardous interactions with other drugs
Adrenergic neurone blockers: antagonise hypotensive effect.

Anaesthetics: increased risk of arrhythmias with volatile general anaesthetics.

Antidepressants: tricyclics may cause hypertension and arrhythmias; MAOIs and moclobemide may cause hypertensive crisis.

Beta-blockers: can cause severe hypertension.
Clonidine: possibly increased risk of hypertension.

Dopaminergics: effects possibly increased by entacapone; avoid with rasagiline.

Sympathomimetics: effects possibly enhanced by dopexamine.

Metabolism

Extensively metabolised by catechol-O-methyltransferase (COMT), and monoamine oxidase (MAO).
Up to 16% of an intravenous dose is excreted unchanged in the urine with methylated and deaminated metabolites in free and conjugated forms.

storage

Store at +4°C