L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
Synonym(s):L -γ-Glutamyl-p-nitroanilide
- CAS NO.:67953-08-6
- Empirical Formula: C11H14ClN3O5
- Molecular Weight: 303.7
- MDL number: MFCD00039054
- EINECS: 267-944-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-18 21:14:07
What is L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE?
Description
L-γ-Glutamyl-p-nitroanilide (67953-08-6; GPNA) is a substrate for γ-glutamyl transpeptidase. GPNA is used for the determination of γ-glutamyl transpeptidase hydrolytic activity via spectrophotometric monitoring of p-nitroaniline released by the action of the enzyme on GPNA.1 GPNA has also been shown to be an inhibitor of glutamine uptake – solute-linked carrier family A1 member 5 (SLC1A5).2?Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.3
The Uses of L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
L-Glutamic acid gamma-(p-nitroanilide) is used in methods of treating cancers having a deregulated NRF2/KEAP1 pathway.
What are the applications of Application
L-Glutamic acid γ-(p-nitroanilide) hydrochloride is a substrate for gamma-glutamyl transpeptidase (GGT).
References
1) Meister?et al. (1981),?γ-Glutamyl transpeptidase; Methods Enzymol.,?77?237 2) Esslinger?et al. (2005),?N-gamma-aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site; Bioorg. Med. Chem.,?13?1111 3) Nicklin?et al. (2012),?Bidirectional Transport of Amino Acid Regulates mTOR and Autophagy; Cell,?136?521
Properties of L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
storage temp. | 2-8°C |
solubility | Soluble in Water (up to 5 mg/ml). |
form | solid |
color | Off-white |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month. |
EPA Substance Registry System | L-Glutamine, N-(4-nitrophenyl)-, monohydrochloride (67953-08-6) |
Safety information for L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
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