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HomeProduct name listL-4-Fluorophenylalanine

L-4-Fluorophenylalanine

  • CAS NO.:1132-68-9
  • Empirical Formula: C9H10FNO2
  • Molecular Weight: 183.18
  • MDL number: MFCD00063064
  • EINECS: 145-896-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 16:48:35
L-4-Fluorophenylalanine Structural

What is L-4-Fluorophenylalanine?

Chemical properties

white to off-white powder

The Uses of L-4-Fluorophenylalanine

4-Fluoro-L-phenylalanine is a substrate for tyrosine hydroxylase (TH) that has been used to study the regulation of that enzyme.

What are the applications of Application

L-4-Fluoro-phenyl-alanine is a TH substrate which appears to inhibit mitosis and arrest cells in G2

Definition

ChEBI: A L-phenylalanine derivative that is L-phenylalanine in which the hydrogen at position 4 on the benzene ring is replaced by a fluoro group.

Purification Methods

It is recrystallised from aqueous EtOH. The (R)-N-acetyl derivative has m 142-145o, [] D -38.6o (c 8, EtOH). [Bennett & Nieman J Am Chem Soc 72 1800 1950, Beilstein 14 III 1268.]

Properties of L-4-Fluorophenylalanine

Melting point: ~255 °C (dec.)
Boiling point: 313.3±32.0 °C(Predicted)
alpha  -26.5 º (c=1, H2O 25 ºC)
Density  1.1939 (estimate)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form  powder to crystal
pka 2.20±0.10(Predicted)
color  White to Almost white
Water Solubility  Soluble in water and 0.5M HCl (50 mg/ml).
BRN  2416148
CAS DataBase Reference 1132-68-9(CAS DataBase Reference)

Safety information for L-4-Fluorophenylalanine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H332:Acute toxicity,inhalation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for L-4-Fluorophenylalanine

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