L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID
Synonym(s):(3S)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid;L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid;Lycoperodine-1
- CAS NO.：42438-90-4
- Empirical Formula: C12H12N2O2
- Molecular Weight: 216.24
- MDL number: MFCD00272641
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID?
Chemical properties
White to off-white powder
What are the applications of Application
L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid is an indole carboxylic acid compound for proteomics research
Biochem/physiol Actions
TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist.
Properties of L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID
| Melting point: | 289 °C (dec.)(lit.) |
| Boiling point: | 485.0±45.0 °C(Predicted) |
| Density | 1.377±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | soluble1.5mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed) |
| form | powder |
| pka | 2.28±0.20(Predicted) |
| color | white to beige |
| optical activity | [α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1)) |
| CAS DataBase Reference | 42438-90-4(CAS DataBase Reference) |
Safety information for L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P233:Keep container tightly closed. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304:IF INHALED: P312:Call a POISON CENTER or doctor/physician if you feel unwell. P321:Specific treatment (see … on this label). P340:Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362:Take off contaminated clothing and wash before reuse. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P403:Store in a well-ventilated place. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..… |
Computed Descriptors for L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID
| InChIKey | FSNCEEGOMTYXKY-JTQLQIEISA-N |
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