JAS239

CAS NO.：1630288-74-2
Empirical Formula: C31H37ClN2O2
Molecular Weight: 505.1
Update Date: 2024-10-23 13:36:13

What is JAS239?

Description

JAS239 is a novel carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly. JAS239 attenuated choline phosphorylation and viability in a panel of human breast cancer cell lines. Antibody blockade prevented cellular retention of JAS239 indicating direct interaction with ChoKα independent of the choline transporters and catabolic choline pathways. In mice bearing orthotopic MCF7 breast xenografts, optical imaging with JAS239 distinguished tumors overexpressing ChoKα from their empty vector counterparts and delineated tumor margins.

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Phone:+91-8919325074

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product: 1630288-74-2 JAS-239 98%

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