JAK3 INHIBITOR VI
- CAS NO.：856436-16-3
- Empirical Formula: C19H17N3O4S
- Molecular Weight: 383.42098
- MDL number: MFCD09037543
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-13 11:39:26
What is JAK3 INHIBITOR VI?
What are the applications of Application
JAK3 Inhibitor VI is a cell permeable selective inhibitor of JAK3
General Description
A cell-permeable, potent, and reversible inhibitor of Janus kinase 3 (JAK3) (IC50 = 27 nM). Reported to bind to the enzyme active site and prevent IL-2-induced phosphorylation of JAK3 and STAT5. Also reported to inhibit IL-2-induced cell proliferation (IC50 = 760 nM for murine CTLL cells and 250 nM for human T-cells). Shown to alleviate oxazolone-induced ear edema in mice with an efficacy comparable to Dexamethasone (Cat. No. 265005) and displays ~16-fold greater selectivity over JAK2.
Biochem/physiol Actions
Cell permeable: yes
Properties of JAK3 INHIBITOR VI
| storage temp. | +2C to +8C |
| form | Yellow solid |
Safety information for JAK3 INHIBITOR VI
Computed Descriptors for JAK3 INHIBITOR VI
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