ISOXAZOLE-5-CARBOXYLIC ACID

CAS NO.：21169-71-1
Empirical Formula: C4H3NO3
Molecular Weight: 113.07
MDL number: MFCD00156151
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is ISOXAZOLE-5-CARBOXYLIC ACID?

Chemical properties

slightly yellow powder

The Uses of ISOXAZOLE-5-CARBOXYLIC ACID

Reaction conditions were found to allow the exclusive formation of isoxazole-5-carboxylic acid derivatives by conjugate addition, in acidic medium, of hydroxylamine to β-alkoxyvinyl trichloromethyl ketone in synthesis and reactivity of isoxazoles. Isoxazole-5-carboxylic acid participates in the Synthesis and evaluation of acylguanidine FXa inhibitors. 1, 1, 1-trichloro-4-methoxy-3-penten-2-one postulated in the preparation of isoxazole-5-carboxylic acid from trichloroacetyl chloride, ethyl vinyl ether and hydroxylamine is developed in a fully saturated nitrogen atom theerefore there is no possibility of conjugation with 4- substituents.

General Description

Isoxazole-5-carboxylic acid can be obtained via dehydration of 5-trichloromethylisoxazole.

Properties of ISOXAZOLE-5-CARBOXYLIC ACID

Melting point:	144-148 °C(lit.)
Boiling point:	211.74°C (rough estimate)
Density	1.5808 (rough estimate)
refractive index	1.4543 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	2.29±0.10(Predicted)
form	Powder
color	Slightly yellow
Water Solubility	Slightly soluble in water.
Sensitive	Moisture Sensitive
CAS DataBase Reference	21169-71-1(CAS DataBase Reference)

Safety information for ISOXAZOLE-5-CARBOXYLIC ACID

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.