Isothiazolinones
Synonym(s):5-chloro-2-methyl-2h-isothiazolin-3-one/2-methyl-2h-isothiazol-3-one
- CAS NO.:26172-55-4
- Empirical Formula: C4H4ClNOS
- Molecular Weight: 149.6
- MDL number: MFCD00792550
- EINECS: 247-500-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-14 16:18:08
What is Isothiazolinones?
Description
Methy1chloro-isothiazolinone (MCI) is contained, along with methylisothiazolinone (MI), in Kathon cosmetic grade (CG) and MCI/MI. It is irritant and sensitizer.
The Uses of Isothiazolinones
A isothiazolidin-3-one derivative as antimicrobial. It was tested for inhibition of PCAF activity. 5-Chloroisothiazolinones showed the most potent inhibition of PCAF.
Background
Methylchloroisothiazolinone (MCI) is an isothiazolinone commonly used as a preservative with antibacterial and antifungal properties. It is found within many commercially available cosmetics, lotions, and makeup removers. It is also a known dermatological sensitizer and allergen; some of its side effects include flaky or scaly skin, breakouts, redness or itchiness, and moderate to severe swelling in the eye area. The American Contact Dermatitis Society named Methylchloroisothiazolinone the Contact Allergen of the Year for 2013.
Sensitivity to Methylchloroisothiazolinone may be identified with a clinical patch test.
Indications
Methylchloroisothiazolinone is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years of age and older.
What are the applications of Application
5-Chloro-2-methyl-4-isothiazolin-3-one (CMI/MI > 2.0) is an isothiazolinone and preservative agent with antimicrobial and antifungal properties.
Metabolism
Not Available
Properties of Isothiazolinones
Melting point: | 42-45?C |
Boiling point: | 109.7°C |
Density | 1.25 (14% aq.) |
storage temp. | Refrigerator |
Safety information for Isothiazolinones
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H412:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Isothiazolinones
Abamectin manufacturer
Melzer Chemicals Pvt Ltd
Earthchem Laboratories P Ltd
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