Isothiazolinones

Synonym(s):5-chloro-2-methyl-2h-isothiazolin-3-one/2-methyl-2h-isothiazol-3-one

CAS NO.：26172-55-4
Empirical Formula: C4H4ClNOS
Molecular Weight: 149.6
MDL number: MFCD00792550
EINECS: 247-500-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:08:57

What is Isothiazolinones?

Description

Methy1chloro-isothiazolinone (MCI) is contained, along with methylisothiazolinone (MI), in Kathon cosmetic grade (CG) and MCI/MI. It is irritant and sensitizer.

Chemical properties

Liquid

The Uses of Isothiazolinones

A isothiazolidin-3-one derivative as antimicrobial. It was tested for inhibition of PCAF activity. 5-Chloroisothiazolinones showed the most potent inhibition of PCAF.

The Uses of Isothiazolinones

Isocil(R) MW-14 is a high performance biocide for preserving metal working fluids, hydraulic fluids, polymer emulsions, pigment dispersions. Suggested applications: preservative concentrate. Very low level.

The Uses of Isothiazolinones

Isocil(R) PC is a cost-effective antimicrobial for personal care formulations. Suggested applications: personal care preservative.

The Uses of Isothiazolinones

Isocil(R) RW is a high performance industrial microbiocide for use in recirculating water cooling towers, wood, mold and mildew control, pulp and paper mills, air washer systems. Suggested applications: Industrial water treatment. Very low use levels.

Background

Methylchloroisothiazolinone (MCI) is an isothiazolinone commonly used as a preservative with antibacterial and antifungal properties. It is found within many commercially available cosmetics, lotions, and makeup removers. It is also a known dermatological sensitizer and allergen; some of its side effects include flaky or scaly skin, breakouts, redness or itchiness, and moderate to severe swelling in the eye area. The American Contact Dermatitis Society named Methylchloroisothiazolinone the Contact Allergen of the Year for 2013.
Sensitivity to Methylchloroisothiazolinone may be identified with a clinical patch test.

Indications

Methylchloroisothiazolinone is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years of age and older.

What are the applications of Application

5-Chloro-2-methyl-4-isothiazolin-3-one (CMI/MI > 2.0) is an isothiazolinone and preservative agent with antimicrobial and antifungal properties.

Definition

ChEBI: A 1,2-thiazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom and a chlorine at C-5. It is a powerful biocide and preservative and is the major active ingredient in the commercial product KathonTM.

Metabolism

Not Available

Properties of Isothiazolinones

Melting point:	42-45?C
Boiling point:	109.7°C
Density	1.25 (14% aq.)
refractive index	n20/D 1.378
storage temp.	Refrigerator
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
pka	-4.06±0.40(Predicted)
Stability:	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	26172-55-4(CAS DataBase Reference)
NIST Chemistry Reference	5-Chloro-2-methyl-3(2h)-isothiazolone(26172-55-4)
EPA Substance Registry System	5-Chloro-2-methyl-4-isothiazolin-3-one (26172-55-4)

Safety information for Isothiazolinones

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.