ISOTETRANDRINE
- CAS NO.:477-57-6
- Empirical Formula: C38H42N2O6
- Molecular Weight: 622.76
- MDL number: MFCD00236404
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-06 18:38:04
What is ISOTETRANDRINE?
Description
A bisbenzylisoquinoline alkaloid, shown to be identical with berbamine methyl ether, this base occurs in A therosperrna rnoschaturn, Berberis japonica and Stephania cephalantha. It is dextrorotatory with [α]17D + 146° or[α]20D + 150.7° (c 0.85, CHC13). When recrystallized from MeOH it forms colourless crystals and furnishes a crystalline dimethiodide, m.p. 242°C. Four methoxyl groups and two methylimino groups are present.
The Uses of ISOTETRANDRINE
Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2.
What are the applications of Application
Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2
References
Kondo et al., J. Pharrn. Soc., Japan, 58,920 (1938)
Tomita, Fujita, Morai., ibid, 71,226,301 (1951)
Bick, Clezy, Crow., Austral. J. Chern., 9, III (1956)
Synthesis:
Inubushi et ai., Tetrahedron Lett., 3399 (1968)
Properties of ISOTETRANDRINE
Melting point: | 180-182℃ |
Boiling point: | 710.5±60.0 °C(Predicted) |
Density | 1.172 |
RTECS | NX7285000 |
solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
form | Off-white solid. |
pka | 7.70±0.20(Predicted) |
color | White to light yellow |
Safety information for ISOTETRANDRINE
Computed Descriptors for ISOTETRANDRINE
New Products
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