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HomeProduct name listIsoindoline

Isoindoline

Isoindoline Structural

What is Isoindoline?

Description

Isoindoline can be considered as the “hydrogenated sister” of isoindole which is widespread in nature as heterocyclic core of alkaloids and antibiotics.

The Uses of Isoindoline

Isoindoline is used to make a chiral diamine catalyst from L-proline for the asymmetric acylation of alcohols.1

The Uses of Isoindoline

Isoindolinone and isoindoline pigments are high quality products. They are used in general and high grade industrial paints including original automobile and automotive refinishes, in plastics and for spin dyeing, and in high grade printing inks, especially for metal deco, laminated plastic sheets, and in printing inks for bank notes and securities.

Synthesis Reference(s)

The Journal of Organic Chemistry, 53, p. 5381, 1988 DOI: 10.1021/jo00257a041
Synthetic Communications, 18, p. 2055, 1988 DOI: 10.1080/00397918808068274

Properties of Isoindoline

Melting point: 17 °C (lit.)
Boiling point: 221 °C (lit.)
Density  1.05 g/mL at 25 °C (lit.)
refractive index  n20/D 1.57(lit.)
Flash point: 202 °F
storage temp.  2-8°C
form  Crystalline Powder, Crystals or Flakes, Darkening On Exposure To Light
pka 9.26±0.20(Predicted)
color  White to off-white
CAS DataBase Reference 496-12-8(CAS DataBase Reference)

Safety information for Isoindoline

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Isoindoline

InChIKey GWVMLCQWXVFZCN-UHFFFAOYSA-N

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