ISOCORYDINE HYDROCHLORIDE
Synonym(s):11-Hydroxy-1,2,10-trimethoxyaporphine;Isocorydine hydrochloride;Luteanine
- CAS NO.：475-67-2
- Empirical Formula: C20H23NO4
- Molecular Weight: 341.4
- MDL number: MFCD00075905
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is ISOCORYDINE HYDROCHLORIDE?
Description
Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities. It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 μM. Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC50 value of 12.6 μM. It is cytotoxic to A549 lung cancer cells (IC50 = 197.7 μM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 μg/ml, respectively). Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.
The Uses of ISOCORYDINE HYDROCHLORIDE
Isocorydine Hydrochloride is the hydrochloric acid of Isocorydine(I797000) which is an alkaloid inhibitor of eukaryotic kinases.
The Uses of ISOCORYDINE HYDROCHLORIDE
sedative, cholinergic
The Uses of ISOCORYDINE HYDROCHLORIDE
Isocorydine is an alkaloid inhibitor of eukaryotic kinases.
Definition
ChEBI: Isocorydine is an aporphine alkaloid.
References
See Isocorydine
Properties of ISOCORYDINE HYDROCHLORIDE
| Melting point: | 216-220 °C(lit.) |
| Boiling point: | 477.03°C (rough estimate) |
| alpha | D20 +195° (chloroform) |
| Density | 1.2064 (rough estimate) |
| refractive index | 1.5614 (estimate) |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Cryst. |
| pka | 9.41±0.20(Predicted) |
Safety information for ISOCORYDINE HYDROCHLORIDE
Computed Descriptors for ISOCORYDINE HYDROCHLORIDE
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