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HomeProduct name listISOCORYDINE HYDROCHLORIDE

ISOCORYDINE HYDROCHLORIDE

Synonym(s):11-Hydroxy-1,2,10-trimethoxyaporphine;Isocorydine hydrochloride;Luteanine

  • CAS NO.:475-67-2
  • Empirical Formula: C20H23NO4
  • Molecular Weight: 341.4
  • MDL number: MFCD00075905
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-30 20:13:01
ISOCORYDINE HYDROCHLORIDE Structural

What is ISOCORYDINE HYDROCHLORIDE?

Description

Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities. It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 μM. Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC50 value of 12.6 μM. It is cytotoxic to A549 lung cancer cells (IC50 = 197.7 μM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 μg/ml, respectively). Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.

The Uses of ISOCORYDINE HYDROCHLORIDE

Isocorydine Hydrochloride is the hydrochloric acid of Isocorydine(I797000) which is an alkaloid inhibitor of eukaryotic kinases.

The Uses of ISOCORYDINE HYDROCHLORIDE

sedative, cholinergic

The Uses of ISOCORYDINE HYDROCHLORIDE

Isocorydine is an alkaloid inhibitor of eukaryotic kinases.

Definition

ChEBI: Isocorydine is an aporphine alkaloid.

References

See Isocorydine

Properties of ISOCORYDINE HYDROCHLORIDE

Melting point: 216-220 °C(lit.)
Boiling point: 477.03°C (rough estimate)
alpha  D20 +195° (chloroform)
Density  1.2064 (rough estimate)
refractive index  1.5614 (estimate)
solubility  Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form  Cryst.
pka 9.41±0.20(Predicted)

Safety information for ISOCORYDINE HYDROCHLORIDE

Computed Descriptors for ISOCORYDINE HYDROCHLORIDE

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