Isochlorogenic acid A
Synonym(s):3,5-Di-caffeoylquinic acid
- CAS NO.:2450-53-5
- Empirical Formula: C25H24O12
- Molecular Weight: 516.46
- MDL number: MFCD00951290
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-09 09:30:51
What is Isochlorogenic acid A?
Description
3,5-Dicaffeoylquinic acid (3,5-DCQA) is a natural phenolic compound that has been found in L. japonica, I. kaushue, and other plants. It has antioxidant, anti-inflammatory, and antiviral biological activities. 3,5-DCQA scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals in a cell-free assay (IC50 = 71.8 μM) and inhibits superoxide production in human neutrophils activated by N-formyl-Met-Leu-Phe (fMLF) and cytochalasin B (IC50 = 1.92 μM). It inhibits HIV-1 integrase 3''-end processing, strand transfer, and disintegration in a cell-free assay (IC50s = 0.33, 0.34, and 0.66 μg/ml, respectively) and inhibits HIV-1-induced cytotoxicity in MT-2 cells (ED50 = 1 μg/ml). In vivo, 3,5-DCQA (25 mg/kg) protects mice from acute lung injury induced by LPS and decreases neutrophil count in bronchoalveolar lavage fluid (BALF).
The Uses of Isochlorogenic acid A
Isochlorogenic Acid A is a phenolic compound shown to provide protection against oxidative stress cells. DNA protective agent.
What are the applications of Application
3,5-Di-O-caffeoylquinic acid is an antioxidant that has been shown to have antiproliferative activity
Definition
ChEBI: 3,5-di-O-caffeoyl quinic acid is a carboxylic ester that is the diester obtained by the condensation of the hydroxy groups at positions 3 and 5 of (-)-quinic acid with the carboxy group of trans-caffeic acid. Isolated from Brazilian propolis and Suaeda glauca, it exhibits hepatoprotective and cytotoxic activities. It has a role as a metabolite, a hepatoprotective agent and an antineoplastic agent. It is a cyclitol carboxylic acid and a carboxylic ester. It is functionally related to a (-)-quinic acid and a trans-caffeic acid.
Properties of Isochlorogenic acid A
Melting point: | >175°C (dec.) |
Boiling point: | 826.2±65.0 °C(Predicted) |
Density | 1?+-.0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 3.54±0.50(Predicted) |
form | Off-white to yellow/brown crystalline solid. |
color | Off-White to Pale Yellow |
Stability: | Hygroscopic |
Safety information for Isochlorogenic acid A
Computed Descriptors for Isochlorogenic acid A
InChIKey | KRZBCHWVBQOTNZ-PSEXTPKNSA-N |
New Products
Tubulysin M (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin A Tubulysin E Tubulysin H 2,2-Difluoropropylamine hydrochloride Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE CYCLOBUTYLAMINE HYDROCHLORIDE 4,4-DIFLUOROPIPERIDINE 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH Lubiprostone Magnesium Trisilicate Latanoprostene Bunod Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
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