Ingenol

CAS NO.：30220-46-3
Empirical Formula: C20H28O5
Molecular Weight: 348.43
MDL number: MFCD27980538
SAFETY DATA SHEET (SDS)
Update Date: 2024-01-04 11:05:11

What is Ingenol?

Description

Ingenol is a diterpenoid related to phorbol, derived from the milkweed plant E. peplus. It is a protein kinase C activator that displays a K_i value of 30 μM and an ED₅₀ value of 27 μM in vitro. Most ingenol esters are tumor-promoting. However, ingenol mebutate possesses anti-tumor activity when used topically for actinic keratosis.

The Uses of Ingenol

Ingenol, is the analogue of Ingenol 3-Angelate (I655800), which has anti-tumor activity when used topically for the treatment of actinic keratosis.

What are the applications of Application

Ingenol is a weak protein kinase C activator

Definition

ChEBI: A tetracyclic diterpenoid that is 1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-11-one substituted at positions 5, 5a and 6 by hydroxy groups, positions 1, 1, 7 and 9 by met yl groups, position 4 by a hydroxymethyl group and position 1 by an oxo group (the 1aR,2S,5R,5aR,6S,8aS,9R,10aR diastere mer).

Properties of Ingenol

Melting point:	153 °C
Boiling point:	523.8±50.0 °C(Predicted)
Density	1.33±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: soluble
form	film
pka	12.06±0.70(Predicted)
color	colorless

Safety information for Ingenol

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.