INDOLIZINE
- CAS NO.:274-40-8
- Empirical Formula: C8H7N
- Molecular Weight: 117.15
- MDL number: MFCD00030189
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:37
What is INDOLIZINE?
The Uses of INDOLIZINE
Indolizine is a useful chemical intermediate
Definition
ChEBI: Indolizine is a mancude organic heterobicyclic parent and a member of indolizines.
Synthesis Reference(s)
Journal of the American Chemical Society, 81, p. 1456, 1959 DOI: 10.1021/ja01515a044
The Journal of Organic Chemistry, 22, p. 589, 1957 DOI: 10.1021/jo01356a621
Purification Methods
Purify indolizine through an alumina column in *C6H6 and elute with *C6H6 (toluene could be used instead). The eluate contained in the fluorescent band (using UV light 365mn) is collected, evaporated and the crystalline residue is sublimed twice at 40-50o/0.2-0.5mm. The colourless crystals darken on standing and should be stored in dark sealed containers. If the original sample is dark in color then it should be covered with water and steam distilled. The colourless crystals in the distillate are collected and dried between filter paper and sublimed. It protonates on C3 in aqueous acid. It should give one fluorescent spot on paper chromatography (Whatman 1) in 3% aqueous ammonia and in n-BuOH/AcOH/H2O (4:1:1). The picrate has m 101o from EtOH. [Armarego J Chem Soc 226 1964, Armarego J Chem Soc (B) 191 1966, Scholtz Chem Ber 45 734 1912, Beilstein 20 II 200, 20 III/IV 3195.]
Properties of INDOLIZINE
Melting point: | 75°C |
Boiling point: | 205.05°C |
Density | 1.0224 (rough estimate) |
refractive index | 1.5211 (estimate) |
storage temp. | <0°C |
CAS DataBase Reference | 274-40-8 |
Safety information for INDOLIZINE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for INDOLIZINE
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