Indole-2-carboxaldehyde

CAS NO.：19005-93-7
Empirical Formula: C9H7NO
Molecular Weight: 145.16
MDL number: MFCD03001425
SAFETY DATA SHEET (SDS)
Update Date: 2024-03-26 17:16:27

What is Indole-2-carboxaldehyde?

The Uses of Indole-2-carboxaldehyde

Indole-2-carboxaldehyde is a useful starter in indole and natural product chemistry.

Synthesis Reference(s)

Tetrahedron, 36, p. 2505, 1980 DOI: 10.1016/0040-4020(80)80230-4

Purification Methods

Recrystallise the indole from aqueous MeOH (m 141-142o), Et2O (m 138o) or sublime it in vacuo (m 138o).The N,N-dimethylhydrazone [127280-17-5] has m 105-106o (from hexane/*C6H6). The thiosemicarbazone has m 229o (dec) (from 50% aqueous EtOH) [Doyle et al. J Chem Soc 2854 1956]. The 2,4-dinitrophenylhydrazone has m 315-320o (dec) (from pyridine/MeOH). [Suzuki et al. Chem Pharm Bull Jpn 39 2170 1991, Beilstein 21 III/IV 3754.]

Properties of Indole-2-carboxaldehyde

Melting point:	138-142 °C
Boiling point:	339.1±15.0 °C(Predicted)
Density	1.278±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in Methanol.
form	Solution
pka	15.05±0.30(Predicted)
color	Clear pale yellow to grey
Sensitive	Air Sensitive
CAS DataBase Reference	19005-93-7(CAS DataBase Reference)

Safety information for Indole-2-carboxaldehyde

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.