Indazole

Synonym(s):1,2-Benzodiazole;1,2-Benzopyrazole

CAS NO.：271-44-3
Empirical Formula: C7H6N2
Molecular Weight: 118.14
MDL number: MFCD00005691
EINECS: 205-978-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-05 11:59:05

What is Indazole?

Chemical properties

white to beige needle-like crystalline powder

The Uses of Indazole

1H-Indazole is used in organic synthesis, it can react with butyryl chloride and 1-butyryl-1H-indazole. It is also used in synthesis of several small molecule inhibitors as potential cancer therapeutics.

What are the applications of Application

Indazole is a heterocyclic aromatic compound

Definition

ChEBI: 1H-indazole is an indazole. It is a tautomer of a 2H-indazole.

Synthesis Reference(s)

Journal of the American Chemical Society, 79, p. 5242, 1957 DOI: 10.1021/ja01576a047
Organic Syntheses, Coll. Vol. 3, p. 475, 1955

Purification Methods

Crystallise indazole from water, sublime it in vacuo, then recrystallise it from pet ether (b 60-80o). The picrate crystallises from Et2O with m 136o. [Ainsworth Org Synth Coll Vol IV 536 1963, Beilstein 23 III/IV 1055, 23/6 V 156.]

Properties of Indazole

Melting point:	145-148 °C (lit.)
Boiling point:	270 °C/743 mmHg (lit.)
Density	1.4220 (rough estimate)
refractive index	1.5500 (estimate)
Flash point:	270°C
storage temp.	Inert atmosphere,Room Temperature
pka	14.00±0.10(Predicted)
form	Needle-Like Crystalline Powder
color	White to beige
Water Solubility	SOLUBLE IN HOT WATER
Merck	14,4936
BRN	109676
CAS DataBase Reference	271-44-3(CAS DataBase Reference)
NIST Chemistry Reference	1H-Indazole(271-44-3)
EPA Substance Registry System	Indazole (271-44-3)

Safety information for Indazole

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.