Indazole
Synonym(s):1,2-Benzodiazole;1,2-Benzopyrazole
- CAS NO.：271-44-3
- Empirical Formula: C7H6N2
- Molecular Weight: 118.14
- MDL number: MFCD00005691
- EINECS: 205-978-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-09 17:25:19
What is Indazole?
Chemical properties
white to beige needle-like crystalline powder
The Uses of Indazole
1H-Indazole is used in organic synthesis, it can react with butyryl chloride and 1-butyryl-1H-indazole. It is also used in synthesis of several small molecule inhibitors as potential cancer therapeutics.
What are the applications of Application
Indazole is a heterocyclic aromatic compound
Definition
ChEBI: 1H-indazole is an indazole. It is a tautomer of a 2H-indazole.
Synthesis Reference(s)
Journal of the American Chemical Society, 79, p. 5242, 1957 DOI: 10.1021/ja01576a047
Organic Syntheses, Coll. Vol. 3, p. 475, 1955
Purification Methods
Crystallise indazole from water, sublime it in vacuo, then recrystallise it from pet ether (b 60-80o). The picrate crystallises from Et2O with m 136o. [Ainsworth Org Synth Coll Vol IV 536 1963, Beilstein 23 III/IV 1055, 23/6 V 156.]
Properties of Indazole
| Melting point: | 145-148 °C (lit.) |
| Boiling point: | 270 °C/743 mmHg (lit.) |
| Density | 1.4220 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| Flash point: | 270°C |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 14.00±0.10(Predicted) |
| form | Needle-Like Crystalline Powder |
| color | White to beige |
| Water Solubility | SOLUBLE IN HOT WATER |
| Merck | 14,4936 |
| BRN | 109676 |
| CAS DataBase Reference | 271-44-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 1H-Indazole(271-44-3) |
| EPA Substance Registry System | Indazole (271-44-3) |
Safety information for Indazole
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Indazole
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