INDATRALINE HYDROCHLORIDE

Synonym(s):(±)-trans-3-(3,4-Dichlorophenyl)-N-methyl-1-indanamine hydrochloride;Lu 19-005

CAS NO.：96850-13-4
Empirical Formula: C16H16Cl3N
Molecular Weight: 328.66
MDL number: MFCD00083178
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 23:16:16

What is INDATRALINE HYDROCHLORIDE?

The Uses of INDATRALINE HYDROCHLORIDE

Indatraline Hydrochloride?inhibits the synaptosomal uptake of 3,4-dihydroxyphenylethylamine (dopamine, DA), noradrenaline (NA), and 5-hydroxytryptamine (5-HT, serotonin).

The Uses of INDATRALINE HYDROCHLORIDE

Indatraline hydrochloride has been used:

as a competitive inhibitor of 3H-dopamine ([³H]DA) to study its effects on trans-activator of transcription (Tat) protein on cocaine-induced inhibition of uptake of [3H]DA
as a dopamine transport blocker to study its effects on trace amine-associated receptor 1 (TAAR1)-transfected mice cells
as a nonselective monoamine transport inhibitor to study its anti-angiogenic activities in glioblastoma multiforme (GBM)

What are the applications of Application

Indatraline hydrochloride is an inhibitor of ST, DAT, and SLC6A2

Biochem/physiol Actions

Indatraline is a non-selective monoamine transport inhibitor. It inhibits the reuptake of neurotransmitters, such as serotonin, norepinephrine and dopamine. It exhibits anti-depressant and anti-angiogenic effects. Indatraline also plays a role in inducing autophagy.

storage

Desiccate at RT

Properties of INDATRALINE HYDROCHLORIDE

storage temp.	2-8°C
solubility	0.1 M HCl: 1 mg/mL
form	solid
color	white

Safety information for INDATRALINE HYDROCHLORIDE

Signal word	Warning
Pictogram(s)	Environment GHS09
GHS Hazard Statements	H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes	P273:Avoid release to the environment.