Imidapril
- CAS NO.:89371-37-9
- Empirical Formula: C20H27N3O6
- Molecular Weight: 405.44
- MDL number: MFCD00870777
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:01
What is Imidapril?
Description
Imidapril is a new ACE inhibitor launched in Japan as a once-daily therapy for hypertension. Its active metabolite has more potent inhibitory effects on all tissue ACES from spontaneously hypertensive rats (SHRs) and Wistar Kyoto rats (WKYs) than many other ACE inhibitors including enalapril and captopril. It has a very long duration of action. In strokeprone spontaneously hypertensive rats (SHRSP), imidapril is effective in stroke prevention at a considerably lower dose than enalapril. This stroke preventive effect has been suggested to be primarily by an indirect mechanism related to the amelioration of kidney dysfunction.
Chemical properties
White Solid
Originator
Tanabe (Japan)
The Uses of Imidapril
Angiotensin converting enzyme (ACE) inhibitor. Antihypertensive
What are the applications of Application
Imidapril hydrochloride is an inhibitor of ACE (angiotension converting enzyme)
Definition
ChEBI: Imidapril is a member of the class of imidazolidines that is (4S)-1-methyl-2-oxoimidazolidine-4-carboxylic acid in which the hydrogen of the imidazolidine nitrogen has been substituted by (1S)-1-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}ethyl group. It is the prodrug for imidaprilat, an ACE inhibitor used for the treatment of chronic heart failure. It has a role as an antihypertensive agent, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and a prodrug. It is a dipeptide, a member of imidazolidines, a dicarboxylic acid monoester, a secondary amino compound, an ethyl ester and a N-acylurea.
brand name
Tanatril; Novarok
Properties of Imidapril
Melting point: | 195-197°C |
Boiling point: | 577.0±60.0 °C(Predicted) |
alpha | D20 -71.7° (c = 0.5 in ethanol) |
Density | 1.266±0.06 g/cm3(Predicted) |
storage temp. | -20°C Freezer |
pka | 2.44±0.20(Predicted) |
form | Solid |
color | White to off-white |
CAS DataBase Reference | 89371-37-9(CAS DataBase Reference) |
Safety information for Imidapril
Computed Descriptors for Imidapril
New Products
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