IKD-8344
- CAS NO.:129046-69-1
- Empirical Formula: C48H76O12
- Molecular Weight: 845.11
- MDL number: MFCD00916500
- Update Date: 2023-05-21 10:59:17
What is IKD-8344?
Description
IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties.1,2,3 It is cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng/ml).1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg/ml) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.2,3 It is active against T. spiralis in vitro and in vivo.1
References
1. Minami, Y., Yoshida, K., Azuma, R., et al. Structure of a novel macrodiolide antibiotic IKD-
2. Hwang, E.I., Yun, B.S., Yeo, W.H., et al. Compound IKD-
3. Loutet, S.A., El-Halfawy, O.M., Jassem, A.N., et al. Identification of synergists that potentiate the action of polymyxin B against Burkholderia cenocepacia Int. J. Antimicrob. Agents 46(4),376-380(2015).
Properties of IKD-8344
storage temp. | Store at -20°C |
solubility | DMSO: soluble; Ethanol: soluble; Methanol: soluble |
form | A solid |
Safety information for IKD-8344
Computed Descriptors for IKD-8344
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