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HomeProduct name listIKD-8344

IKD-8344

  • CAS NO.:129046-69-1
  • Empirical Formula: C48H76O12
  • Molecular Weight: 845.11
  • MDL number: MFCD00916500
  • Update Date: 2023-05-21 10:59:17
IKD-8344 Structural

What is IKD-8344?

Description

IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties.1,2,3 It is cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng/ml).1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg/ml) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.2,3 It is active against T. spiralis in vitro and in vivo.1

References

1. Minami, Y., Yoshida, K., Azuma, R., et al. Structure of a novel macrodiolide antibiotic IKD-8344 Tetrahedron Lett. 33(48),7373-7376(1992).
2. Hwang, E.I., Yun, B.S., Yeo, W.H., et al. Compound IKD-8344, a selective growth inhibitor against the mycelial form of Candida albicans, isolated from Streptomyces sp. A6792 J. Microbiol. Biotechnol. 15(4),909-912(2005).
3. Loutet, S.A., El-Halfawy, O.M., Jassem, A.N., et al. Identification of synergists that potentiate the action of polymyxin B against Burkholderia cenocepacia Int. J. Antimicrob. Agents 46(4),376-380(2015).

Properties of IKD-8344

storage temp.  Store at -20°C
solubility  DMSO: soluble; Ethanol: soluble; Methanol: soluble
form  A solid

Safety information for IKD-8344

Computed Descriptors for IKD-8344

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