Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listIKD-8344

IKD-8344

  • CAS NO.:129046-69-1
  • Empirical Formula: C48H76O12
  • Molecular Weight: 845.11
  • MDL number: MFCD00916500
  • Update Date: 2023-05-21 10:59:17
IKD-8344 Structural

What is IKD-8344?

Description

IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties.1,2,3 It is cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng/ml).1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg/ml) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.2,3 It is active against T. spiralis in vitro and in vivo.1

References

1. Minami, Y., Yoshida, K., Azuma, R., et al. Structure of a novel macrodiolide antibiotic IKD-8344 Tetrahedron Lett. 33(48),7373-7376(1992).
2. Hwang, E.I., Yun, B.S., Yeo, W.H., et al. Compound IKD-8344, a selective growth inhibitor against the mycelial form of Candida albicans, isolated from Streptomyces sp. A6792 J. Microbiol. Biotechnol. 15(4),909-912(2005).
3. Loutet, S.A., El-Halfawy, O.M., Jassem, A.N., et al. Identification of synergists that potentiate the action of polymyxin B against Burkholderia cenocepacia Int. J. Antimicrob. Agents 46(4),376-380(2015).

Properties of IKD-8344

storage temp.  Store at -20°C
solubility  DMSO: soluble; Ethanol: soluble; Methanol: soluble
form  A solid

Safety information for IKD-8344

Computed Descriptors for IKD-8344

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.