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HomeProduct name listIDO-IN-1

IDO-IN-1

IDO-IN-1 Structural

What is IDO-IN-1?

Biological Activity

ido-in-1 is an indoleamine-2,3-dioxygenase (ido) inhibitor.ido is expressed in various tissues throughout the body but mainly in cells within the immune system where it is induced in dendritic cells and macrophages at sites of inflammation by cytokines. the overexpression of ido has been implicated in a variety of diseases, such as cancer, neurodegenerative disorders, age-related cataract, and hiv encephalitis.

in vitro

in previous study, ido-in-1 was found to have improved in-vitro human intrinsic clearances without loss in ido cellular potency [1].

in vivo

ido-in-1 analog, named 5l, was chosen for further in vivo studies because of its improved physical chemical properties compared to ido-in-1. the efficacy of 5l was tested in c57bl/6 mice with gmcsf-secreting b16 tumors, where 1-mt had previously shown activity. results showed that the dose-dependent inhibition of tumor growth was linked to increasing exposures of 5l in plasma. in addition, a maximal effect of 50% tumor growth control (tgc) was observed when 5l was subcutaneously administered at 75 mg/kg bid. for comparison, 1-mt showed around 45% tgc when administered as subcutaneous pellets [1].

References

[1] yue ew, et al. discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. j med chem. 2009 dec 10;52(23):7364-7.

Properties of IDO-IN-1

Boiling point: 512.6±60.0 °C(Predicted)
Density  2.03±0.1 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  ≥29.1 mg/mL in DMSO; ≥25.9 mg/mL in EtOH; insoluble in H2O
form  crystalline solid
pka 7.54±0.69(Predicted)
color  White to gray

Safety information for IDO-IN-1

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for IDO-IN-1

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