IDAZOXAN HYDROCHLORIDE
Synonym(s):(±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride;2-(1,4-Benzodioxan-2-yl)-2-imidazoline hydrochloride, RX781094, Idazoxa, α₂-Adrenoceptor Antagonist, Idazoxan Hydrochloride;Idazoxan Hydrochloride - CAS 79944-56-2 - Calbiochem;RX 781094
- CAS NO.：79944-56-2
- Empirical Formula: C11H13ClN2O2
- Molecular Weight: 240.69
- MDL number: MFCD00069293
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:11
What is IDAZOXAN HYDROCHLORIDE?
Chemical properties
mp 207-209°C
The Uses of IDAZOXAN HYDROCHLORIDE
Idazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems.
The Uses of IDAZOXAN HYDROCHLORIDE
An α-adrenoceptor antagonist; in rat brain Idazoxan is a pure antagonist and it has a selectivity for α2- over α1-receptors markedly superior to Piperoxane, Yohimbine, or Rauwolscine. Antiparkinsonian.
The Uses of IDAZOXAN HYDROCHLORIDE
Antiparkinsonian;Alpha2 agonist
What are the applications of Application
Idazoxan hydrochloride is an α2-AR adrenoceptor antagonist and I2 imidazoline receptor agonist.
Biological Activity
α 2 -adrenoceptor antagonist, and I 2 ligand, selective over I 1 sites (pK i values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I 1 , I 2 , α 2A , α 2B , and α 2C receptors respectively).
Biochem/physiol Actions
α2-adrenoceptor antagonist; I2?imidazoline receptor agonist; I1?imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).
Properties of IDAZOXAN HYDROCHLORIDE
| Melting point: | 207-208° |
| storage temp. | Store at RT |
| solubility | H2O: 300 mg/mL |
| form | Powder |
| color | White to off-white |
| Water Solubility | Soluble to 100 mM in water |
| Stability: | Hygroscopic |
Safety information for IDAZOXAN HYDROCHLORIDE
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
| Precautionary Statement Codes |
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for IDAZOXAN HYDROCHLORIDE
New Products
Tubulysin H Tubulysin F Tubulysin C Tubulysin E tetrahydro-4-methyl-2H-pyran Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate CYCLOBUTYLAMINE HYDROCHLORIDE 2,2-Difluoropropylamine hydrochloride 2H-Pyran, 4-ethynyltetrahydro- 3-Aminocyclobutanone hydrochloride 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Fuel shell Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Magnesium Trisilicate Lubiprostone Latanoprostene Bunod Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
You may like
-
Idazoxan hydrochloride CAS 79944-56-2View Details
79944-56-2 -
(R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateView Details
2416850-45-6 -
methyl 3-fluoro-4- thiomorpholino phenylcarbamateView Details
2760359-22-4 -
Fuel shell 98%View Details
-
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
151767-02-1 Montelukast Sodium IP/USP 98%View Details
151767-02-1 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8