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HomeProduct name listIDAZOXAN HYDROCHLORIDE

IDAZOXAN HYDROCHLORIDE

Synonym(s):(±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride;2-(1,4-Benzodioxan-2-yl)-2-imidazoline hydrochloride, RX781094, Idazoxa, α₂-Adrenoceptor Antagonist, Idazoxan Hydrochloride;Idazoxan Hydrochloride - CAS 79944-56-2 - Calbiochem;RX 781094

IDAZOXAN HYDROCHLORIDE Structural

What is IDAZOXAN HYDROCHLORIDE?

Chemical properties

mp 207-209°C

The Uses of IDAZOXAN HYDROCHLORIDE

Idazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems.

The Uses of IDAZOXAN HYDROCHLORIDE

An α-adrenoceptor antagonist; in rat brain Idazoxan is a pure antagonist and it has a selectivity for α2- over α1-receptors markedly superior to Piperoxane, Yohimbine, or Rauwolscine. Antiparkinsonian.

The Uses of IDAZOXAN HYDROCHLORIDE

Antiparkinsonian;Alpha2 agonist

What are the applications of Application

Idazoxan hydrochloride is an α2-AR adrenoceptor antagonist and I2 imidazoline receptor agonist.

Biological Activity

α 2 -adrenoceptor antagonist, and I 2 ligand, selective over I 1 sites (pK i values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I 1 , I 2 , α 2A , α 2B , and α 2C receptors respectively).

Biochem/physiol Actions

α2-adrenoceptor antagonist; I2?imidazoline receptor agonist; I1?imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).

Properties of IDAZOXAN HYDROCHLORIDE

Melting point: 207-208°
storage temp.  Store at RT
solubility  H2O: 300 mg/mL
form  Powder
color  White to off-white
Water Solubility  Soluble to 100 mM in water
Stability: Hygroscopic

Safety information for IDAZOXAN HYDROCHLORIDE

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
Precautionary Statement Codes P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for IDAZOXAN HYDROCHLORIDE

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