Hydroxypioglitazone
- CAS NO.：146062-44-4
- Empirical Formula: C19H20N2O4S
- Molecular Weight: 372.44
- MDL number: MFCD00916074
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-07-12 16:47:46
What is Hydroxypioglitazone?
Description
Hydroxy pioglitazone is a major metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone (Item Nos. 71745 | 22263 | 10028). It is formed from pioglitazone by the cytochrome P450 (CYP) isoform CYP2C8 with minor contributions from CYP3A4. Hydroxy pioglitazone binds to PPARγ (Ki = 1.2 μM) and activates PPARγ in a time-resolved FRET (TR-FRET) assay (EC50 = 2.1 μM).
Chemical properties
Off-White Solid
The Uses of Hydroxypioglitazone
A metabolite of Pioglitazone (P471000).
What are the applications of Application
Hydroxy Pioglitazone (M-IV) is a pioglitazone metabolite
Definition
ChEBI: Hydroxypioglitazone is a member of the class of thiazolidenediones that is the hydroxy derivative of pioglitazone. It has a role as a human xenobiotic metabolite. It is a member of thiazolidinediones, a member of pyridines and an aromatic ether. It is functionally related to a pioglitazone.
Properties of Hydroxypioglitazone
| Melting point: | 157-1580C |
| Boiling point: | 627.6±55.0 °C(Predicted) |
| Density | 1.325±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| form | Solid |
| pka | 6.35±0.50(Predicted) |
| color | White to Off-White |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 146062-44-4 |
Safety information for Hydroxypioglitazone
Computed Descriptors for Hydroxypioglitazone
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