Hydroxypioglitazone

CAS NO.：146062-44-4
Empirical Formula: C19H20N2O4S
Molecular Weight: 372.44
MDL number: MFCD00916074
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 13:36:13

What is Hydroxypioglitazone?

Description

Hydroxy pioglitazone is a major metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone (Item Nos. 71745 | 22263 | 10028). It is formed from pioglitazone by the cytochrome P450 (CYP) isoform CYP2C8 with minor contributions from CYP3A4. Hydroxy pioglitazone binds to PPARγ (K_i = 1.2 μM) and activates PPARγ in a time-resolved FRET (TR-FRET) assay (EC₅₀ = 2.1 μM).

Chemical properties

Off-White Solid

The Uses of Hydroxypioglitazone

A metabolite of Pioglitazone (P471000).

What are the applications of Application

Hydroxy Pioglitazone (M-IV) is a pioglitazone metabolite

Definition

ChEBI: Hydroxypioglitazone is a member of the class of thiazolidenediones that is the hydroxy derivative of pioglitazone. It has a role as a human xenobiotic metabolite. It is a member of thiazolidinediones, a member of pyridines and an aromatic ether. It is functionally related to a pioglitazone.

Properties of Hydroxypioglitazone

Melting point:	157-1580C
Boiling point:	627.6±55.0 °C(Predicted)
Density	1.325±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer, Under Inert Atmosphere
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
form	Solid
pka	6.35±0.50(Predicted)
color	White to Off-White
Stability:	Hygroscopic
CAS DataBase Reference	146062-44-4