Hydroxy(2-naphthyl)Methanephosphonic Acid
- CAS NO.：132541-52-7
- Empirical Formula: C11H11O4P
- Molecular Weight: 238.18
- MDL number: MFCD27943631
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-04 15:50:00
What is Hydroxy(2-naphthyl)Methanephosphonic Acid?
Description
HNMPA is a cell impermeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation, including insulin receptor tyrosine kinase activity. It does not affect protein kinase C or cyclic AMP-dependent protein kinase activities. HNMPA inhibits the insulin-stimulated autophosphorylation of the 95-kDa β-subunit of the insulin receptor with an IC50 value of 200 μM in vitro.
The Uses of Hydroxy(2-naphthyl)Methanephosphonic Acid
Insulin receptor tyrosine kinase (IRTK) inhibitor.
The Uses of Hydroxy(2-naphthyl)Methanephosphonic Acid
A selective insulin receptor tyrosine kinase inhibitor
References
[1]. baltensperger k, lewis re, woon cw, et al. catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. proc natl acad sci u s a. 1992 sep 1;89(17):7885-9.
[2]. moon mj, kim hy, park s, et al. insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1. mol cells. 2011 oct;32(4):389-95.
Properties of Hydroxy(2-naphthyl)Methanephosphonic Acid
| Melting point: | >180oC(dec.) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO, Methanol |
| form | White solid. |
| color | White to Off-White |
Safety information for Hydroxy(2-naphthyl)Methanephosphonic Acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. |
Computed Descriptors for Hydroxy(2-naphthyl)Methanephosphonic Acid
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