HYDROXY ITRACONAZOLE
- CAS NO.：112559-91-8
- Empirical Formula: C35H38Cl2N8O5
- Molecular Weight: 721.63
- MDL number: MFCD28964104
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:03:09
What is HYDROXY ITRACONAZOLE?
Description
Hydroxy itraconazole (OH-ITZ) is an active metabolite of the antifungal agent itraconazole . Itraconazole is metabolized by the cytochrome P450 isoform 3A4 (CYP3A4) to form hydroxy itraconazole. Hydroxy itraconazole exhibits in vitro antifungal activity (MIC = 0.019, 0.078, and 0.078 mg/ml against C. albicans, A. fumigatus, and C. neoformans, respectively). Plasma concentration of hydroxy itraconazole is directly correlated to that of the parent compound and is used as an indicator of prophylaxis for fungal infections.
Chemical properties
Off-White Crystalline Solid
The Uses of HYDROXY ITRACONAZOLE
A metabolite of Itraconazole, an orally active antimycotic structurally related to Ketoconazole
The Uses of HYDROXY ITRACONAZOLE
A metabolite of Itraconazole, an orally active antimycotic structurally related to Ketoconazole. It is a COVID19-related research product.
What are the applications of Application
Hydroxy Itraconazole is an active antimycotic metabolite
Properties of HYDROXY ITRACONAZOLE
| Melting point: | 76-78°C |
| Boiling point: | 884.7±75.0 °C(Predicted) |
| Density | 1.44±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 14.72±0.20(Predicted) |
| color | White to Pale Beige |
Safety information for HYDROXY ITRACONAZOLE
Computed Descriptors for HYDROXY ITRACONAZOLE
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Ivermectin EP Impurity B Rimegepant Impurity 3 Tubulysin I Tubulysin F Tubulysin E Tubulysin H Imeglimin Hydrochloride IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Calcium Sodium Phosphosilicate IH Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 5-Aminophthalazine 2-(2,4-Dibutoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate Methyl 4-amino-3-(4-phenylpiperazin-1-yl)benzoate Benzene butanoic acid, 2-hydroxy-3-iodo-, methyl ester 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine (4-(1-Hydroxycyclobutyl)phenyl)boronic acid pinacol ester 4-BROMO-5-FLUORONAPHTHALEN-2-OLRelated products of tetrahydrofuran
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