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HomeProduct name listHydrocortisone IMpurity I

Hydrocortisone IMpurity I

Hydrocortisone IMpurity I Structural

What is Hydrocortisone IMpurity I?

The Uses of Hydrocortisone IMpurity I

14α-Hydroxycortisol (Hydrocortisone EP Impurity I) is an impurity of Hydrocortisone (H714615), a topical corticosteroid (1), but more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland (2). Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.

Properties of Hydrocortisone IMpurity I

Melting point: 241-242 °C
Boiling point: 602.3±55.0 °C(Predicted)
Density  1.35±0.1 g/cm3(Predicted)
pka 12.10±0.70(Predicted)

Safety information for Hydrocortisone IMpurity I

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Hydrocortisone IMpurity I

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