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HomeProduct name listHOMATROPINE METHYL BROMIDE

HOMATROPINE METHYL BROMIDE

Synonym(s):Homatropine methobromide;Homatropine methylbromide

  • CAS NO.:80-49-9
  • Empirical Formula: C17H24BrNO3
  • Molecular Weight: 370.28
  • MDL number: MFCD00050292
  • EINECS: 201-284-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-31 18:15:48
HOMATROPINE METHYL BROMIDE Structural

What is HOMATROPINE METHYL BROMIDE?

Chemical properties

White or almost white, crystalline powder or colourless crystals

The Uses of HOMATROPINE METHYL BROMIDE

anticholinergic (opthalmic)

The Uses of HOMATROPINE METHYL BROMIDE

Homatropine methylbromide or Methylhomatropine bromide is a quaternary ammonium salt of methylhomatropine. Methylhomatropine is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. Methylhomatropine does not cross the blood–brain barrier. Methylhomatropine is used, in addition to papaverine, as component of mild drugs that help "flush" the bile.

Background

Homatropine methylbromide is a quaternary ammonium muscarinic acetylcholine receptor antagonist belonging to the group of medicines called anti-muscarinics. Homatropine is used to treat duodenal or stomach ulcers or intestine problems. It can be used together with antacids or other medicine in the treatment of peptic ulcer. It may also be used to prevent nausea, vomiting, and motion sickness.

Indications

Used in conjunction with antacids or histamine H2-receptor antagonists in the treatment of peptic ulcers, gastric ulcers and duodenal ulcers, to reduce further gastric acid secretion and delay gastric emptying.

brand name

Equipin (Mission); Homapin (Mission).

General Description

Homatropinemethylbromide, 3 -hydroxy-8-methyl-1 H,5 H-tropaniumbromide mandelate (Novatropine, Mesopin), occurs as a bitter,white, odorless powder and is affected by light. The compoundis readily soluble in water and alcohol but insoluble inether. The pH of a 1% solution is 5.9 and that of a 10% solutionis 4.5. Although a solution of the compound yields a precipitatewith alkaloidal reagents, such as mercuric potassiumiodide test solution, addition of alkali hydroxides or carbonatesdoes not cause the precipitate that occurs with nonquaternarynitrogen salts (e.g., atropine, homatropine).

Pharmacokinetics

Homatropine methylbromide belongs to the group of medicines called anti-muscarinics. Homatropine is used to treat duodenal or stomach ulcers or intestine problems. It can be used together with antacids or other medicine in the treatment of peptic ulcer. It may also be used to prevent nausea, vomiting, and motion sickness.

Clinical Use

Homatropine methylbromide is transported poorly acrossthe blood-brain barrier because of its quaternary ammoniumgroup and, therefore, has far fewer stimulant properties thanatropine. It does have all the characteristic peripheralparasympathetic depressant properties of atropine and isused to reduce oversecretion and to relieve GI spasms.

Metabolism

Not Available

Properties of HOMATROPINE METHYL BROMIDE

Melting point: 192°C
storage temp.  -20°C Freezer
solubility  Freely soluble in water, soluble in ethanol 96 per cent
form  neat
form  Solid
color  White to Off-White
Merck  14,4730
CAS DataBase Reference 80-49-9(CAS DataBase Reference)
EPA Substance Registry System Homatropine methylbromide (80-49-9)

Safety information for HOMATROPINE METHYL BROMIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

Computed Descriptors for HOMATROPINE METHYL BROMIDE

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