HO-PEG10-CH2CH2COOH
- CAS NO.：2375611-66-6
- Empirical Formula: C23H46O13
- Molecular Weight: 530.6
- MDL number: MFCD34470047
- Update Date: 2024-10-28 16:48:35
What is HO-PEG10-CH2CH2COOH?
Biological Activity
Hydroxy-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Properties of HO-PEG10-CH2CH2COOH
| Boiling point: | 614.7±55.0 °C(Predicted) |
| Density | 1.143±0.06 g/cm3(Predicted) |
| pka | 4.28±0.10(Predicted) |
Safety information for HO-PEG10-CH2CH2COOH
Computed Descriptors for HO-PEG10-CH2CH2COOH
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