HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS
- CAS NO.：29400-42-8
- Empirical Formula: C33H44O8
- Molecular Weight: 568.7
- MDL number: MFCD32689348
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS?
Description
Helvolic acid is a mycotoxin originally isolated from A. fumigatus that has broad-spectrum antibiotic activity against Gram-positive and Gram-negative bacteria. At 4-16 mg/L, it acted synergistically with erythromycin (500-2,000 mg/L) in vitro on five multi-drug resistant strains of S. aureus. At 10 mg/kg/d, it reduced tumor growth and prolonged survival synergistically with cyclophosphamide (20 mg/kg/d) in a mouse model of sarcoma but had no effect when administered alone.
The Uses of HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS
Helvolic acid is a mycotoxin with antibacterial activity.
What are the applications of Application
Helvolic acid is a mycotoxin with antibacterial activity
Definition
ChEBI: A steroid C-21 acid having a 29-nordammarane skeleton substituted with an acetoxy group at C-16 and oxo groups at C-3 and -7, with double bonds at C-1, -17(20) and -24.
Properties of HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS
| Melting point: | 215° |
| Boiling point: | 552.56°C (rough estimate) |
| alpha | D25 -121° (chloroform) |
| Density | 1.1062 (rough estimate) |
| refractive index | 1.4900 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMF:30.0(Max Conc. mg/mL);52.75(Max Conc. mM) DMSO:20.0(Max Conc. mg/mL);35.17(Max Conc. mM) Ethanol:20.0(Max Conc. mg/mL);35.17(Max Conc. mM) |
| form | A crystalline solid |
| pka | 4.05±0.41(Predicted) |
| color | White to off-white |
Safety information for HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS
Computed Descriptors for HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS
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