HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS

CAS NO.：29400-42-8
Empirical Formula: C33H44O8
Molecular Weight: 568.7
MDL number: MFCD32689348
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 13:36:13

What is HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS?

Description

Helvolic acid is a mycotoxin originally isolated from A. fumigatus that has broad-spectrum antibiotic activity against Gram-positive and Gram-negative bacteria. At 4-16 mg/L, it acted synergistically with erythromycin (500-2,000 mg/L) in vitro on five multi-drug resistant strains of S. aureus. At 10 mg/kg/d, it reduced tumor growth and prolonged survival synergistically with cyclophosphamide (20 mg/kg/d) in a mouse model of sarcoma but had no effect when administered alone.

The Uses of HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS

Helvolic acid is a mycotoxin with antibacterial activity.

What are the applications of Application

Helvolic acid is a mycotoxin with antibacterial activity

Definition

ChEBI: A steroid C-21 acid having a 29-nordammarane skeleton substituted with an acetoxy group at C-16 and oxo groups at C-3 and -7, with double bonds at C-1, -17(20) and -24.

Properties of HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS

Melting point:	215°
Boiling point:	552.56°C (rough estimate)
alpha	D25 -121° (chloroform)
Density	1.1062 (rough estimate)
refractive index	1.4900 (estimate)
storage temp.	2-8°C
solubility	DMF:30.0(Max Conc. mg/mL);52.75(Max Conc. mM) DMSO:20.0(Max Conc. mg/mL);35.17(Max Conc. mM) Ethanol:20.0(Max Conc. mg/mL);35.17(Max Conc. mM)
form	A crystalline solid
pka	4.05±0.41(Predicted)
color	White to off-white