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HomeProduct name listHELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS

HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS

HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS Structural

What is HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS?

Description

Helvolic acid is a mycotoxin originally isolated from A. fumigatus that has broad-spectrum antibiotic activity against Gram-positive and Gram-negative bacteria. At 4-16 mg/L, it acted synergistically with erythromycin (500-2,000 mg/L) in vitro on five multi-drug resistant strains of S. aureus. At 10 mg/kg/d, it reduced tumor growth and prolonged survival synergistically with cyclophosphamide (20 mg/kg/d) in a mouse model of sarcoma but had no effect when administered alone.

The Uses of HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS

Helvolic acid is a mycotoxin with antibacterial activity.

What are the applications of Application

Helvolic acid is a mycotoxin with antibacterial activity

Definition

ChEBI: A steroid C-21 acid having a 29-nordammarane skeleton substituted with an acetoxy group at C-16 and oxo groups at C-3 and -7, with double bonds at C-1, -17(20) and -24.

Properties of HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS

Melting point: 215°
Boiling point: 552.56°C (rough estimate)
alpha  D25 -121° (chloroform)
Density  1.1062 (rough estimate)
refractive index  1.4900 (estimate)
storage temp.  2-8°C
solubility  DMF:30.0(Max Conc. mg/mL);52.75(Max Conc. mM)
DMSO:20.0(Max Conc. mg/mL);35.17(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);35.17(Max Conc. mM)
form  A crystalline solid
pka 4.05±0.41(Predicted)
color  White to off-white

Safety information for HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS

Computed Descriptors for HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS

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