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HomeProduct name listHA14-1

HA14-1

Synonym(s):2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester;Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate

HA14-1 Structural

What is HA14-1?

The Uses of HA14-1

HA14-1 is a cell-permeable, nonpeptidic Bcl-2 inhibitor.

What are the applications of Application

HA14-1 is a cell-permeable, nonpeptidic Bcl-2 inhibitor

Definition

ChEBI: 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylic acid ethyl ester is a 1-benzopyran.

Biological Activity

Cell-permeable inhibitor of Bcl-2 protein (IC 50 ~ 9 μ M); acts by binding to the surface pocket. Disrupts Bax/Bcl-2 interaction and induces apoptosis of tumor cells.

Biochem/physiol Actions

HA 14-1 is a nonpeptide apoptosis inducer; Bcl-2 antagonist.

Properties of HA14-1

Melting point: 105 °C
Density  1.480
storage temp.  Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility  DMSO: 26 mg/mL
form  powder
color  White to light yellow
CAS DataBase Reference 65673-63-4

Safety information for HA14-1

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for HA14-1

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