HA14-1

Synonym(s):2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester;Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate

CAS NO.：65673-63-4
Empirical Formula: C17H17BrN2O5
Molecular Weight: 409.23
MDL number: MFCD00218213
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-07 13:31:19

What is HA14-1?

The Uses of HA14-1

HA14-1 is a cell-permeable, nonpeptidic Bcl-2 inhibitor.

What are the applications of Application

HA14-1 is a cell-permeable, nonpeptidic Bcl-2 inhibitor

Definition

ChEBI: 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylic acid ethyl ester is a 1-benzopyran.

Biological Activity

Cell-permeable inhibitor of Bcl-2 protein (IC 50 ~ 9 μ M); acts by binding to the surface pocket. Disrupts Bax/Bcl-2 interaction and induces apoptosis of tumor cells.

Biochem/physiol Actions

HA 14-1 is a nonpeptide apoptosis inducer; Bcl-2 antagonist.

Properties of HA14-1

Melting point:	105 °C
Density	1.480
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: 26 mg/mL
form	powder
color	White to light yellow
CAS DataBase Reference	65673-63-4

Safety information for HA14-1

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection.