H2N-PEG4-Propyne

Synonym(s):3,6,9,12-Tetraoxapentadec-14-yn-1-amine;Acetylene-PEG4-amine;H₂N-PEG4-propyne;Triethylene glycol 2-aminoethyl propargyl ether

CAS NO.：1013921-36-2
Empirical Formula: C11H21NO4
Molecular Weight: 231.29
MDL number: MFCD22380736
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 23:16:16

What is H2N-PEG4-Propyne?

Description

Propargyl-PEG4-amine has a propargyl group and an amine group. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls, etc. The propargyl group can form triazole linkage with azide-bearing biomolecules.

The Uses of H2N-PEG4-Propyne

1-Amino-3,6,9,12-tetraoxapentadec-14-yne is used as a acetylene containing reagent with PEG spacer and carboxyl reactivity. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification of carboxylic acid containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.

Properties of H2N-PEG4-Propyne

Boiling point:	315.9±32.0 °C(Predicted)
Density	1.037±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO, DMF, DCM, THF, or chloroform.
pka	8.74±0.10(Predicted)
form	Solid
color	Pale Yellow

Safety information for H2N-PEG4-Propyne

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.