H2N-PEG11-CH2CH2COOH
- CAS NO.：1616426-12-0
- Empirical Formula: C25H51NO13
- Molecular Weight: 573.67
- Update Date: 2024-04-07 18:44:46
What is H2N-PEG11-CH2CH2COOH?
Biological Activity
Amino-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
Properties of H2N-PEG11-CH2CH2COOH
| Boiling point: | 637.6±55.0 °C(Predicted) |
| Density | 1.125±0.06 g/cm3(Predicted) |
| pka | 4.28±0.10(Predicted) |
Safety information for H2N-PEG11-CH2CH2COOH
Computed Descriptors for H2N-PEG11-CH2CH2COOH
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