H-THR-PHE-LEU-LEU-ARG-NH2 TRIFLUOROACETATE SALT

Synonym(s):L-Threonyl-L-phenylalanyl-L-leucyl-L-leucyl- L-argininamide trifluoroacetate salt;Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt

Empirical Formula: C33H54F3N9O8
Molecular Weight: 761.83
MDL number: MFCD05663482
Update Date: 2023-04-23 13:52:06

H-THR-PHE-LEU-LEU-ARG-NH2 TRIFLUOROACETATE SALT Structural

What is H-THR-PHE-LEU-LEU-ARG-NH2 TRIFLUOROACETATE SALT?

The Uses of H-THR-PHE-LEU-LEU-ARG-NH2 TRIFLUOROACETATE SALT

TFLLR-NH₂ trifluoroacetate salt has been used as a protease-activated receptor-1 (PAR-1) agonist to study its effects on hippocampal CA1 pyramidal neurons and Swell1 knock out mice (cKO).

Biochem/physiol Actions

TFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2. Protease-activated receptors (PARs) are present on various organs including, plateles, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing. Specificly PAR ligands enhance glutamatergic excitatory transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices.

Properties of H-THR-PHE-LEU-LEU-ARG-NH2 TRIFLUOROACETATE SALT

storage temp.	-20°C
form	lyophilized powder
color	white to tan

Safety information for H-THR-PHE-LEU-LEU-ARG-NH2 TRIFLUOROACETATE SALT

Computed Descriptors for H-THR-PHE-LEU-LEU-ARG-NH2 TRIFLUOROACETATE SALT

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