H-GLY-TYR-PRO-GLY-GLN-VAL-OH
Synonym(s):Glycyl-L-tyrosyl-L-prolyl-glycyl-L-glutaminyl-L-valine trifluoroacetate salt;Gly-Tyr-Pro-Gly-Gln-Val trifluoroacetate salt;PAR 4 (1-6)
- CAS NO.：225779-44-2
- Empirical Formula: C28H41N7O9
- Molecular Weight: 619.67
- MDL number: MFCD02181012
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is H-GLY-TYR-PRO-GLY-GLN-VAL-OH?
Description
PAR4 (1-6) is a peptide agonist of proteinase-activated receptor 4 (PAR4) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR4 and residues 48-53 of the full-length sequence. It activates PAR4 and the cleavage site mutant PAR4R47A when used at a concentration of 500 μM. PAR4 (1-6) induces platelet aggregation of isolated washed human platelets when used at a concentration of 1 mM but does not affect clotting time induced by factor VIIa, soluble tissue factor, and collagen in an ex vivo coagulation assay.
Properties of H-GLY-TYR-PRO-GLY-GLN-VAL-OH
| storage temp. | -15°C
|
| solubility | H2O: >2mg/mL |
| form | powder |
| color | white to tan |
Safety information for H-GLY-TYR-PRO-GLY-GLN-VAL-OH
Computed Descriptors for H-GLY-TYR-PRO-GLY-GLN-VAL-OH
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