GW 6471
Synonym(s):N-((2S)-2-(((1Z)-1-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)prop-1-enyl)amino)-3-(4-(2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy)phenyl)propyl)propanamide
- CAS NO.：880635-03-0
- Empirical Formula: C35H36F3N3O4
- Molecular Weight: 619.67
- MDL number: MFCD07784503
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 15:53:33
What is GW 6471?
The Uses of GW 6471
GW 6471 is a peroxisome proliferator-activated receptor α (PPARα) antagonist. GW 6471 has been shown to enhance the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR.
What are the applications of Application
GW6471 is a complete inhibitor of PPARα that allows interaction with co-repressors
General Description
GW6471 prevents apoptosis and cell cycle arrest at G0/G1 in renal cell carcinoma. It reduces enhanced fatty acid oxidation and oxidative phosphorylation associated with glycolysis inhibition.
Biochem/physiol Actions
GW6471 is a PPARα antagonist, which completely inhibits GW409544-induced activation of PPARα with an IC50 = 0.24 μM. GW6471 induces a PPARα conformation that interacts efficiently with co-repressors.
storage
Store at +4°C
Properties of GW 6471
| Density | 1.204±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 15 mg/mL |
| form | solid |
| pka | 15.90±0.46(Predicted) |
| color | off-white |
Safety information for GW 6471
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for GW 6471
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