GUVACINE HYDROCHLORIDE
- CAS NO.：498-96-4
- Empirical Formula: C6H9NO2
- Molecular Weight: 127.14
- MDL number: MFCD01365700
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-08-23 18:01:39
What is GUVACINE HYDROCHLORIDE?
The Uses of GUVACINE HYDROCHLORIDE
Guvacine Hydrochloride is a GABA uptake inhibitor (hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1) (1,2,3). Gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain (4). Guvacine Hydrochloride may be useful for treating neuropsychiatric disorders.
Definition
ChEBI: A alpha,beta-unsaturated monocarboxylic acid that is nicotinic acid which has been hydrogenated at the 1-2 and 5-6 positions of the pyridine ring.
Biological Activity
Specific GABA uptake inhibitor. IC 50 values are 14, 58, 119 and 1870 mM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.
Properties of GUVACINE HYDROCHLORIDE
| Melting point: | 295°C (rough estimate) |
| Boiling point: | 235.91°C (rough estimate) |
| Density | 1.1931 (rough estimate) |
| refractive index | 1.4645 (estimate) |
| storage temp. | Store at RT |
| solubility | H2O: soluble |
| form | solid |
| pka | 3.61±0.20(Predicted) |
| color | white |
| CAS DataBase Reference | 498-96-4 |
Safety information for GUVACINE HYDROCHLORIDE
Computed Descriptors for GUVACINE HYDROCHLORIDE
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
![N-(3-CHLOROPHENYL)-8-METHOXY-5-OXO-1,5-DIHYDRO-2H-CHROMENO[3,4-C]PYRIDINE-3(4H)-CARBOXAMIDE](https://img.chemicalbook.in/StructureFile/ChemBookStructure7/GIF/CB8430298.gif)
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![1,2,5,6-TETRAHYDRO-1-[2-[[(DIPHENYLMETHYLENE)AMINO]OXY]ETHYL]-3-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE](https://img.chemicalbook.in/CAS/GIF/145645-62-1.gif)
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