GUVACINE HYDROCHLORIDE
- CAS NO.：498-96-4
- Empirical Formula: C6H9NO2
- Molecular Weight: 127.14
- MDL number: MFCD01365700
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-08-23 18:01:39
What is GUVACINE HYDROCHLORIDE?
The Uses of GUVACINE HYDROCHLORIDE
Guvacine Hydrochloride is a GABA uptake inhibitor (hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1) (1,2,3). Gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain (4). Guvacine Hydrochloride may be useful for treating neuropsychiatric disorders.
Definition
ChEBI: A alpha,beta-unsaturated monocarboxylic acid that is nicotinic acid which has been hydrogenated at the 1-2 and 5-6 positions of the pyridine ring.
Biological Activity
Specific GABA uptake inhibitor. IC 50 values are 14, 58, 119 and 1870 mM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.
Properties of GUVACINE HYDROCHLORIDE
| Melting point: | 295°C (rough estimate) |
| Boiling point: | 235.91°C (rough estimate) |
| Density | 1.1931 (rough estimate) |
| refractive index | 1.4645 (estimate) |
| storage temp. | Store at RT |
| solubility | H2O: soluble |
| form | solid |
| pka | 3.61±0.20(Predicted) |
| color | white |
| CAS DataBase Reference | 498-96-4 |
Safety information for GUVACINE HYDROCHLORIDE
Computed Descriptors for GUVACINE HYDROCHLORIDE
New Products
2,2-diethoxyethanethioamide (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin C Tubulysin B Tubulysin I 2,2-Difluoropropanol 4,4-DIFLUOROPIPERIDINE 4,4-DIFLUOROCYCLOHEXANAMINE 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 4-(Benzyloxy)-3-bromophenylacetic Acid 2,2-Difluoropropylamine hydrochloride Imeglimin Hydrochloride IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Fuel shell 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Magnesium Trisilicate Latanoprostene Bunod Lubiprostone Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
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