GSK2795039
Synonym(s):GSK 2795039;GSK-2795039;N-(1-Isopropyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide
- CAS NO.：1415925-18-6
- Empirical Formula: C23H26N6O2S
- Molecular Weight: 450.56
- MDL number: MFCD30489720
- Update Date: 2024-11-14 20:10:21
What is GSK2795039?
Biological Activity
GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. It inhibits reactive oxygen species (ROS) production, NADPH depletion and reduces apoptosis.
in vitro
GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells.
Apoptosis Analysis p>
| Cell Line: | PC12 cells |
| 25 μM | |
| Incubation Time: | < td class="col2"> 24 hours|
| Result: | Reduced apoptosis among PC12 cells. | td>
storage
Store at -20°C
Properties of GSK2795039
| Boiling point: | 691.5±65.0 °C(Predicted) |
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF:30.0(Max Conc. mg/mL);66.58(Max Conc. mM) DMSO:66.27(Max Conc. mg/mL);147.07(Max Conc. mM) DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.44(Max Conc. mM) Ethanol:20.0(Max Conc. mg/mL);44.39(Max Conc. mM) |
| form | A solid |
| pka | 6.99±0.30(Predicted) |
| color | White to yellow |
Safety information for GSK2795039
Computed Descriptors for GSK2795039
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile Diclofenac Potassium Ornidazole IP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Aceclofenac IP/BP/EP Nimesulide BP SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION Methylcobalamin (vitamin B12) SODIUM METHYL PARABEN SODIUM VALPROATE Racecadotril XANTHAN GUMRelated products of tetrahydrofuran
![7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine](https://img.chemicalbook.in/CAS/GIF/1337531-36-8.gif)
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