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HomeProduct name listGSK-626616

GSK-626616

Synonym(s):(5Z)-2-(2,6-Dichloroanilino)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolone;(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone;(5Z)-5-(6-Quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5H)-one;(Z)-2-(2,6-Dichlorophenylamino)-5-(quinoxalin-6-ylmethylene)thiazol-4(5H)-one;

GSK-626616 Structural

What is GSK-626616?

The Uses of GSK-626616

GSK-626616 is a potent and selective DYRK inhibitor (IC50 = 0.7 nM for DYRK3, similar potency for DYRK1 and 2). Exhibits ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened. Enhances number of CFU-E stimulated by Epo from human marrow. Increases hemoglobin levels in anemic mice. Orally bioavailable.

storage

Store at +4°C

Properties of GSK-626616

Melting point: 281 - 282oC
Boiling point: 574.8±60.0 °C(Predicted)
Density  1.55±0.1 g/cm3(Predicted)
storage temp.  Refrigerator, under inert atmosphere
solubility  Chloroform (Slightly, Heated), Methanol (Slightly)
form  Solid
pka -0.94±0.20(Predicted)
color  Pale Yellow to Light Yellow

Safety information for GSK-626616

Computed Descriptors for GSK-626616

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