GAMMA-CHLOROBUTYROPHENONE

CAS NO.：939-52-6
Empirical Formula: C10H11ClO
Molecular Weight: 182.65
MDL number: MFCD00001005
EINECS: 213-362-1
SAFETY DATA SHEET (SDS)
Update Date: 2023-01-11 10:46:38

What is GAMMA-CHLOROBUTYROPHENONE?

The Uses of GAMMA-CHLOROBUTYROPHENONE

4-Chlorobutyrophenone may be used in the preparation of silyl enol ether, Z-4-chloro-1-phenyl-1-trimethylsilyloxybut-1-ene. It may be used as starting material in the preparation of 8-arylimidazopyridines.

Synthesis Reference(s)

Journal of the American Chemical Society, 79, p. 1455, 1957 DOI: 10.1021/ja01563a049

General Description

4-Chlorobutyrophenone is a chloro ketone. Preparation of 4-chlorobutyrophenone is reported.

Purification Methods

Fractionate the ketone several times using a short column. It recrystallises from pet ether at -20o as glistening white rosettes and is filtered at 0o, and dried in a vacuum desiccator over H2SO4. The semicarbazone has m 136-137o. [Conant et al. J Am Chem Soc 46 1882 1924, Cloke J Chem Soc 1174 1929, Hart & Curtis J Am Chem Soc 79 931 1957, Beilstein 7 IV 711.]

Properties of GAMMA-CHLOROBUTYROPHENONE

Melting point:	19-20 °C (lit.)
Boiling point:	130-133 °C4 mm Hg
Density	1.137 g/mL at 25 °C (lit.)
refractive index	n20/D 1.544(lit.)
Flash point:	>230 °F
BRN	878974
CAS DataBase Reference	939-52-6(CAS DataBase Reference)

Safety information for GAMMA-CHLOROBUTYROPHENONE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection.