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HomeProduct name listGALANIN (2-11) PORCINE, RAT

GALANIN (2-11) PORCINE, RAT

GALANIN (2-11) PORCINE, RAT Structural

What is GALANIN (2-11) PORCINE, RAT?

Biological Activity

binding ic50: 1.76 nm for rgalr2; 879 nm for hgalr1galanin is a 29-aa neuropeptide with a complex role in pain processing. galanin receptor subtypes are present in dorsal root ganglia and spinal cord with a differential distribution. three galanin receptors, galr1, galr2 and galr3, have been identified and cloned. ar-m1896 is a specific galanin r2 (galr2) agonist.

in vitro

additional removal of the glycine residue in position 1 resulted in ar-m1896 with almost unchanged galr2 affinity and functional activity, and 500-fold selectivity for galr2-rs over galr1-rs. this compound represents a truly galr2-selective galanin analog and, thus, could be used as a pharmacological tool to differentiate between these two receptors [1].

in vivo

in normal rats mechanical and cold allodynia of the hindpaw are induced by intrathecal infusion of low-dose galanin. the same effect is seen with equimolar doses of ar-m1896 or ar-m961 (an agonist both at galr1 and galr2 receptors). in allodynic bennett model rats, the mechanical threshold dose-dependently increased after intrathecal injection of a high ar-m961dose, whereas no effect was observed in the control or ar-m1896 group. no effect of either compounds was observed in nonallodynic bennett model rats [1].

References

[1] liu hx, brumovsky p, schmidt r, brown w, payza k, hodzic l, pou c, godbout c, hökfelt t. receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via galr1 and galr2 receptors. proc natl acad sci u s a. 2001 aug 14;98(17):9960-4.

Properties of GALANIN (2-11) PORCINE, RAT

Boiling point: 1595.4±65.0 °C(Predicted)
Density  1.291±0.06 g/cm3(Predicted)
storage temp.  −20°C
solubility  Soluble to 1 mg/ml in 20% formic acid
pka 9.82±0.15(Predicted)
form  lyophilized powder

Safety information for GALANIN (2-11) PORCINE, RAT

Computed Descriptors for GALANIN (2-11) PORCINE, RAT

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