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HomeProduct name listFusidine

Fusidine

Synonym(s):Fusidic acid;Ramycin

  • CAS NO.:6990-06-3
  • Empirical Formula: C31H48O6
  • Molecular Weight: 516.72
  • MDL number: MFCD00865135
  • EINECS: 230-256-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-31 20:01:59
Fusidine Structural

What is Fusidine?

Absorption

Sodium fusidic acid tablets have a 91% oral bioavailability. Absorption of the film-coated tablets is complete when compared to a solution, however oral absorption is variable. Oral fusidic acid hemihydrate (suspension) achieved a 22.5% bioavailability in pediatric patients following a 20 milligram/kilogram dose.

Description

Fusidic acid was found in the culture broth of a fungus imperfectus, Fusidium coccineum, by Leo in 1962. It has a steroid struc ture but shows no hormonal activity.

Chemical properties

White Solid

The Uses of Fusidine

Fusidic acid is a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.

The Uses of Fusidine

antibacterial

The Uses of Fusidine

Fusidic acid is a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Dyes and metabolites.

Indications

For the treatment of bacterial infections.

What are the applications of Application

Fusidic acid is a bacteriostatic antibiotic that only works on gram-positive bacteria

Background

An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis. It is often used topically in creams and eyedrops but is available in systemic formulations including tablets and injections.

Definition

ChEBI: A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.

brand name

Fucidine (Bristol-Myers Squibb).

Hazard

Moderately toxic inhibitor of translocation during protein synthesis.

Biological Activity

Fusidic acid shows very strong activity against Staphy lococcus aureus and weak activity against other gram-positive bacteria and gram-negative cocci and Mycobacterium.

Biochem/physiol Actions

Fusidic acid is a tetracyclic triterpenoid with antibiotic activity against Gram-positive bacteria. It is derived from Fusidium coccineum. It shows its activity against anaerobes, corynebacterial, Nocardia, and Neisseria species. Fusidic acid exhibits therapeutic effects against Staphylococcal infections, skin infections.

Pharmacokinetics

Fusidic acid is a bacteriostatic antibiotic and helps prevent bacterial growth while the immune system clears the infection.

Metabolism

Metabolites include dicarboxylic ester/acid, 3-keto fusidic acid, hydroxy fusidic acid, glucuronide fusidic acid and a glycol metabolite.

Properties of Fusidine

Melting point: 190-192°C
Boiling point: 521.49°C (rough estimate)
alpha  D20 -9° (chloroform)
Density  1.0389 (rough estimate)
vapor pressure  0-0Pa at 25℃
refractive index  1.4890 (estimate)
storage temp.  Sealed in dry,2-8°C
solubility  Practically insoluble in water, freely soluble in ethanol (96 per cent)
form  neat
pka pK: 5.35 in water
form  Solid
color  White to Off-White
Water Solubility  2.376-525000μg/L at 25℃
λmax 204nm(H2O)(lit.)
Merck  14,4317
Stability: Hygroscopic
CAS DataBase Reference 6990-06-3(CAS DataBase Reference)

Safety information for Fusidine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P501:Dispose of contents/container to..…

Computed Descriptors for Fusidine

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