Fmoc-Trp(Boc)-OH
Synonym(s):Nα-Fmoc-N(in)-Boc-L -tryptophan;N(in)-Boc-Nα-Fmoc-L -tryptophan;Fmoc-Trp(Boc)-OH;N-α-Fmoc-N-in-t.-Boc-L-tryptophan
- CAS NO.：143824-78-6
- Empirical Formula: C31H30N2O6
- Molecular Weight: 526.58
- MDL number: MFCD00153366
- EINECS: 604-383-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 18:15:42
What is Fmoc-Trp(Boc)-OH?
Chemical properties
White solid
The Uses of Fmoc-Trp(Boc)-OH
Fmoc-Trp(Boc)-OH is a very useful synthetic intermediate. It is used to prepare Trp containing-peptides.
The Uses of Fmoc-Trp(Boc)-OH
Fmoc-Trp(Boc)-OH can be used for the synthesis of analogs of glucagon-like peptide-1 (GLP-1) for the treatment of type 2 diabetes and various peptides by Fmoc solid phase peptide synthesis (SPPS).
General Description
The use of this N-in-Boc protected derivative overcomes most of the problems associated with the preparation of Trp containing-peptides by Fmoc SPPS [1]. Cleavage with TFA generates an N-in-carboxy indole which protects the Trp from alkylation [1, 2, 3] and sulfonation [1, 4, 5, 6, 7]. The N-in-carboxy group is removed under aqueous conditions during normal work-up of the peptide.
The product number for this product was previously 04-12-1103.
To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.
Properties of Fmoc-Trp(Boc)-OH
| Melting point: | ca 97℃ |
| alpha | -21 º (c=1%, DMF) |
| Density | 1.28±0.1 g/cm3(Predicted) |
| refractive index | -20 ° (C=1, DMF) |
| storage temp. | 2-8°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Solid |
| pka | 3.71±0.10(Predicted) |
| color | White to Orange to Green |
| optical activity | [α]20/D 21±2°, c = 1% in DMF |
| Sensitive | Moisture Sensitive |
| BRN | 7698009 |
| CAS DataBase Reference | 143824-78-6(CAS DataBase Reference) |
Safety information for Fmoc-Trp(Boc)-OH
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H317:Sensitisation, Skin H401:Hazardous to the aquatic environment, acute hazard H411:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P321:Specific treatment (see … on this label). P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. |
Computed Descriptors for Fmoc-Trp(Boc)-OH
| InChIKey | ADOHASQZJSJZBT-SANMLTNESA-N |
Fmoc-Trp(Boc)-OH manufacturer
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
You may like
-
Fmoc-Trp(Boc)-OH CAS 143824-78-6View Details
143824-78-6 -
Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N1-tert-butoxycarbonyl-L-tryptophan CAS 143824-78-6View Details
143824-78-6 -
Fmoc-Trp(Boc)-OH 95% CAS 143824-78-6View Details
143824-78-6 -
Fmoc-Trp(Boc)-OH CAS 143824-78-6View Details
143824-78-6 -
Fmoc-Trp(Boc)-OH >98% (HPLC) CAS 143824-78-6View Details
143824-78-6 -
Fmoc-Trp(Boc)-OH, ≥97.0% (HPLC) CAS 143824-78-6View Details
143824-78-6 -
Fmoc-Trp(Boc)-OH 95.00% CAS 143824-78-6View Details
143824-78-6 -
Fmoc-Trp(Boc)-OH CAS 143824-78-6View Details
143824-78-6