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HomeProduct name listFmoc-Trp(Boc)-OH

Fmoc-Trp(Boc)-OH

Synonym(s):Nα-Fmoc-N(in)-Boc-L-tryptophan;N(in)-Boc-Nα-Fmoc-L-tryptophan;Fmoc-Trp(Boc)-OH;N-α-Fmoc-N-in-t.-Boc-L-tryptophan

  • CAS NO.:143824-78-6
  • Empirical Formula: C31H30N2O6
  • Molecular Weight: 526.58
  • MDL number: MFCD00153366
  • EINECS: 604-383-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-31 18:15:42
Fmoc-Trp(Boc)-OH Structural

What is Fmoc-Trp(Boc)-OH?

Chemical properties

White solid

The Uses of Fmoc-Trp(Boc)-OH

Fmoc-Trp(Boc)-OH is a very useful synthetic intermediate. It is used to prepare Trp containing-peptides.

The Uses of Fmoc-Trp(Boc)-OH

Fmoc-Trp(Boc)-OH can be used for the synthesis of analogs of glucagon-like peptide-1 (GLP-1) for the treatment of type 2 diabetes and various peptides by Fmoc solid phase peptide synthesis (SPPS).

General Description

The use of this N-in-Boc protected derivative overcomes most of the problems associated with the preparation of Trp containing-peptides by Fmoc SPPS [1]. Cleavage with TFA generates an N-in-carboxy indole which protects the Trp from alkylation [1, 2, 3] and sulfonation [1, 4, 5, 6, 7]. The N-in-carboxy group is removed under aqueous conditions during normal work-up of the peptide.



The product number for this product was previously 04-12-1103.

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Properties of Fmoc-Trp(Boc)-OH

Melting point: ca 97℃
alpha  -21 º (c=1%, DMF)
Density  1.28±0.1 g/cm3(Predicted)
refractive index  -20 ° (C=1, DMF)
storage temp.  2-8°C
solubility  Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form  Solid
pka 3.71±0.10(Predicted)
color  White to Orange to Green
optical activity [α]20/D 21±2°, c = 1% in DMF
Sensitive  Moisture Sensitive
BRN  7698009
CAS DataBase Reference 143824-78-6(CAS DataBase Reference)

Safety information for Fmoc-Trp(Boc)-OH

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Environment
GHS09
GHS Hazard Statements H317:Sensitisation, Skin
H401:Hazardous to the aquatic environment, acute hazard
H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P321:Specific treatment (see … on this label).
P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

Computed Descriptors for Fmoc-Trp(Boc)-OH

InChIKey ADOHASQZJSJZBT-SANMLTNESA-N

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