Fmoc-O-trityl-L-threonine
Synonym(s):Fmoc-Thr(Trt)-OH;N-α-Fmoc-O-trityl-L-threonine
- CAS NO.：133180-01-5
- Empirical Formula: C38H33NO5
- Molecular Weight: 583.67
- MDL number: MFCD00237034
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-03-28 17:34:19
What is Fmoc-O-trityl-L-threonine?
Chemical properties
White to off-white crystalline powder
General Description
The side-chain Trt group can be selectively removed with 1% TFA in DCM containing 5% TIS, enabling the side-chain hydroxyl group to be selectively modified whilst the derivative is attached to the solid support. This is an excellent derivative for the synthesis of phosphothreonine containing peptides and peptides modified at the threonine side-chain [1]. The use of trityl protected amino acids was shown to result in purer products than when standard t-Bu protected amino acids were utilized [2].
The product number for this product was previously 04-12-1141.
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Properties of Fmoc-O-trityl-L-threonine
| Boiling point: | 753.0±60.0 °C(Predicted) |
| Density | 1.241±0.06 g/cm3(Predicted) |
| storage temp. | Store at -15°C to -25°C. |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Powder |
| pka | 3.31±0.10(Predicted) |
| CAS DataBase Reference | 133180-01-5(CAS DataBase Reference) |
Safety information for Fmoc-O-trityl-L-threonine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H312:Acute toxicity,dermal H332:Acute toxicity,inhalation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P330:Rinse mouth. P363:Wash contaminated clothing before reuse. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P501:Dispose of contents/container to..… |
Computed Descriptors for Fmoc-O-trityl-L-threonine
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