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HomeProduct name listFmoc-O-trityl-L-threonine

Fmoc-O-trityl-L-threonine

Synonym(s):Fmoc-Thr(Trt)-OH;N-α-Fmoc-O-trityl-L-threonine

Fmoc-O-trityl-L-threonine Structural

What is Fmoc-O-trityl-L-threonine?

Chemical properties

White to off-white crystalline powder

General Description

The side-chain Trt group can be selectively removed with 1% TFA in DCM containing 5% TIS, enabling the side-chain hydroxyl group to be selectively modified whilst the derivative is attached to the solid support. This is an excellent derivative for the synthesis of phosphothreonine containing peptides and peptides modified at the threonine side-chain [1]. The use of trityl protected amino acids was shown to result in purer products than when standard t-Bu protected amino acids were utilized [2].

The product number for this product was previously 04-12-1141.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

Properties of Fmoc-O-trityl-L-threonine

Boiling point: 753.0±60.0 °C(Predicted)
Density  1.241±0.06 g/cm3(Predicted)
storage temp.  Store at -15°C to -25°C.
solubility  Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form  Powder
pka 3.31±0.10(Predicted)
CAS DataBase Reference 133180-01-5(CAS DataBase Reference)

Safety information for Fmoc-O-trityl-L-threonine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H312:Acute toxicity,dermal
H332:Acute toxicity,inhalation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P330:Rinse mouth.
P363:Wash contaminated clothing before reuse.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P501:Dispose of contents/container to..…

Computed Descriptors for Fmoc-O-trityl-L-threonine

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