Fmoc-N-Me-Tyr(tBu)-OH

Synonym(s):Fmoc-N-Me-Tyr(tBu)-OH;N-α-Fmoc-N-α-methyl-O-tert-butyl-L-tyrosine

CAS NO.：133373-24-7
Empirical Formula: C29H31NO5
Molecular Weight: 473.56
MDL number: MFCD02684471
SAFETY DATA SHEET (SDS)
Update Date: 2024-03-28 11:33:14

What is Fmoc-N-Me-Tyr(tBu)-OH?

Chemical properties

White powder

What are the applications of Application

Fmoc-Nalpha-methyl-O-t-butyl-L-tyrosine is an Fmoc protected tyrosine derivative

General Description

Fmoc-N-Me-Tyr(tBu)-OH is an Fmoc protected tyrosine derivative that is potentially useful for proteomics studies and solid phase peptide synthesis techniques. Tyrosine is a very important amino acid - one of the few amino acids which is phosphorylated to vary the physical properties of the peptides, and is a precursor for the formation of iodinated thyroid hormones. The Fmoc group is typically removed with a base such as pyridine - an orthogonal de-protection strategy to the acid labilie Boc group.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

(9H-Fluoren-9-yl)methyl carbonochloridate could be used as the starting material to synthesize Fmoc-N-Me-Tyr(tBu)-OH.

Properties of Fmoc-N-Me-Tyr(tBu)-OH

Melting point:	186-191°C
Boiling point:	638.9±55.0 °C(Predicted)
Density	1.208
storage temp.	2-8°C
pka	2.98±0.10(Predicted)
optical activity	[α]22/D -49.0°, c = 0.5% in DMF
CAS DataBase Reference	133373-24-7(CAS DataBase Reference)