Fmoc-N-Me-Tyr(tBu)-OH
Synonym(s):Fmoc-N-Me-Tyr(tBu)-OH;N-α-Fmoc-N-α-methyl-O-tert-butyl-L-tyrosine
- CAS NO.：133373-24-7
- Empirical Formula: C29H31NO5
- Molecular Weight: 473.56
- MDL number: MFCD02684471
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-28 11:33:14
What is Fmoc-N-Me-Tyr(tBu)-OH?
Chemical properties
White powder
What are the applications of Application
Fmoc-Nalpha-methyl-O-t-butyl-L-tyrosine is an Fmoc protected tyrosine derivative
General Description
Fmoc-N-Me-Tyr(tBu)-OH is an Fmoc protected tyrosine derivative that is potentially useful for proteomics studies and solid phase peptide synthesis techniques. Tyrosine is a very important amino acid - one of the few amino acids which is phosphorylated to vary the physical properties of the peptides, and is a precursor for the formation of iodinated thyroid hormones. The Fmoc group is typically removed with a base such as pyridine - an orthogonal de-protection strategy to the acid labilie Boc group.
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
Synthesis
(9H-Fluoren-9-yl)methyl carbonochloridate could be used as the starting material to synthesize Fmoc-N-Me-Tyr(tBu)-OH.
Properties of Fmoc-N-Me-Tyr(tBu)-OH
| Melting point: | 186-191°C |
| Boiling point: | 638.9±55.0 °C(Predicted) |
| Density | 1.208 |
| storage temp. | 2-8°C |
| pka | 2.98±0.10(Predicted) |
| optical activity | [α]22/D -49.0°, c = 0.5% in DMF |
| CAS DataBase Reference | 133373-24-7(CAS DataBase Reference) |
Safety information for Fmoc-N-Me-Tyr(tBu)-OH
Computed Descriptors for Fmoc-N-Me-Tyr(tBu)-OH
| InChIKey | WTLSDEYZKFJXFT-SANMLTNESA-N |
| SMILES | C(O)(=O)[C@H](CC1=CC=C(OC(C)(C)C)C=C1)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C |
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