FMoc-α-Me-Lys(Boc)-OH

CAS NO.：1202003-49-3
Empirical Formula: C27H34N2O6
Molecular Weight: 482.57
MDL number: MFCD17019258
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-27 16:27:43

What is FMoc-α-Me-Lys(Boc)-OH?

Chemical properties

White to off-white powder.

The Uses of FMoc-α-Me-Lys(Boc)-OH

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((tert-butoxycarbonyl)amino)-2-methylhexanoic acid is a reagent in the preparation/biological evaluation of a vapreotide analogs containing (S)-α-methyl-lysine.

The Uses of FMoc-α-Me-Lys(Boc)-OH

Synthesis

Benzyl (2R,3S)-(?)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate (4) was successively alkylated with methyl iodide and 1,4-diiodobutane using a base. In each alkylation step anti-alkylated product formed exclusively. The iodo group was displaced with azide, which served as a precursor for the side-chain amino function. Catalytic hydrogenation with concomitant cleavage of the chiral auxiliary afforded (L)-α-Me-Lys-OH (9) in a total of four steps in good yield. (L)-Fmoc-α-Me-Lys(Boc)-OH (16) was obtained from 9 via regioselective benzyloxycarbonylation. Alternately, (L)-Fmoc-α-Me-Lys(Boc)-OH (16) was obtained via Staudinger reduction of azide (8) in a total of six steps in good yield.

Properties of FMoc-α-Me-Lys(Boc)-OH

Boiling point:	687.9±55.0 °C(Predicted)
Density	1.196±0.06 g/cm3(Predicted)
storage temp.	2-8°C
form	powder
pka	3.92±0.41(Predicted)
color	white

Safety information for FMoc-α-Me-Lys(Boc)-OH

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H336:Specific target organ toxicity,single exposure; Narcotic effects H351:Carcinogenicity H373:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P281:Use personal protective equipment as required. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.