FMOC-ARG(ME,PBF)-OH
- CAS NO.：1135616-49-7
- Empirical Formula: C35H42N4O7S
- Molecular Weight: 662.8
- MDL number: MFCD08064312
- SAFETY DATA SHEET (SDS)
What is FMOC-ARG(ME,PBF)-OH?
Description
FMOC-Arg (ME, PBF)-OH is a kind of protected form of arginine. Arginine is double-protected by butyloxycarbonyl (BOC) and 2, 2, 4, 6, 7-pentamethyldihydrobenzofuran-5-sulfonyl (PBF). It is a derivative for introducing mono-methyl-arginine during Fmoc SPPS. Coupling can be carried out using any standard activation method. PBF protecting group can be removed by TFA-mediated cleavage reaction. As a kind of protected amino acid, it is an important intermediate in various fields such as peptide synthesis, asymmetric synthesis, medicinal chemistry as well as polymer chemistry.
Chemical properties
White powder
The Uses of FMOC-ARG(ME,PBF)-OH
Fmoc-?Arg(Me,?pbf)?-?OH can be used as reactant/reagent in design, synthesis and structure-activity relationship of macrocyclic peptidomimetics that bind to WDR5 and block WDR5-MLL protein-protein interaction.
References
https://www.merckmillipore.com/CN/zh/product/Fmoc-Arg%28Me%2CPbf%29-OH,MDA_CHEM-852105?ReferrerURL=https%3A%2F%2Fguge6.firstguo.com%2F&bd=1
https://en.wikipedia.org/wiki/Peptide_synthesis
Kim, Tae-il, et al. "Arginine-conjugated polypropylenimine dendrimer as a non-toxic and efficient gene delivery carrier." Biomaterials 28.11 (2007): 2061-2067.
Properties of FMOC-ARG(ME,PBF)-OH
| Density | 1.33 |
| storage temp. | Store at -15°C to -25°C. |
| pka | 3.80±0.21(Predicted) |
Safety information for FMOC-ARG(ME,PBF)-OH
Computed Descriptors for FMOC-ARG(ME,PBF)-OH
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