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HomeProduct name listFlumethasone 21-pivalate

Flumethasone 21-pivalate

Synonym(s):6α,9-Difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(2,2-dimethylpropionate);Flumetasone 21-pivalate;NSC 107680

  • CAS NO.:2002-29-1
  • Empirical Formula: C27H36F2O6
  • Molecular Weight: 494.57
  • MDL number: MFCD00079287
  • EINECS: 217-901-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 16:48:35
Flumethasone 21-pivalate Structural

What is Flumethasone 21-pivalate?

Chemical properties

White or almost white, crystalline powder.

The Uses of Flumethasone 21-pivalate

An anti-inflammatory anti-itching corticosteroid found in topical creams.

The Uses of Flumethasone 21-pivalate

flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a pivalate, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.

What are the applications of Application

Flumethasone pivalate is a GR (glucocorticoid receptor) agonist

Definition

ChEBI: Flumethasone pivalate is a pivalate ester, a glucocorticoid, an 11beta-hydroxy steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It has a role as an anti-inflammatory drug and an antipruritic drug. It is functionally related to a flumethasone.

brand name

Locorten (Novartis).

Properties of Flumethasone 21-pivalate

Melting point: >263°C (dec.)
Boiling point: 600.3±55.0 °C(Predicted)
Density  1.27±0.1 g/cm3(Predicted)
storage temp.  Refrigerator
solubility  dioxane: soluble4.0ML, clear, colorless to very faintly yellow (50 mg + 4.0 mL dioxane)
form  solid
pka 11.86±0.70(Predicted)
color  White to Off-White
optical activity [α]25/D 71.0 to 82.0°, c = 1 in dioxane
CAS DataBase Reference 2002-29-1(CAS DataBase Reference)
EPA Substance Registry System Flumethasone-21-pivalate (2002-29-1)

Safety information for Flumethasone 21-pivalate

Signal word Warning
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H351:Carcinogenicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P405:Store locked up.
P501:Dispose of contents/container to..…

Computed Descriptors for Flumethasone 21-pivalate

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