Ethyl propionylacetate
Synonym(s):Ethyl 3-oxovalerate
- CAS NO.：4949-44-4
- Empirical Formula: C7H12O3
- Molecular Weight: 144.17
- MDL number: MFCD00009317
- EINECS: 225-593-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-10 11:33:04
What is Ethyl propionylacetate?
Chemical properties
colourless liquid
The Uses of Ethyl propionylacetate
Ethyl propionylacetate acts as a precursor used in the preparation of 1-ethyl- and 1-n-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid bearing one or two substituents on the benzene ring. Further, it is used to prepare 3-propionyl-2H-cyclohepta[b]furan-2-one.
The Uses of Ethyl propionylacetate
An intermediate of Rosuvastatin.
The Uses of Ethyl propionylacetate
Ethyl propionylacetate has been used in the synthesis of 1-ethyl- and 1-n-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid bearing one or two substituents on the benzene ring.
What are the applications of Application
Ethyl 3-oxovalerate is an intermediate of Rosuvastatin.
Synthesis Reference(s)
Synthesis, p. 829, 1978 DOI: 10.1055/s-1978-24903
General Description
Ethyl propionylacetate reacts with tropolone p-toluenesulfonate in the presence of sodium ethoxide to give 3-propionyl-2H-cyclohepta[b]furan-2-one.
Properties of Ethyl propionylacetate
| Melting point: | 98 °C |
| Boiling point: | 83-84 °C/12 mmHg (lit.) |
| Density | 1.012 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 172 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Miscible with glacial acetic acid. |
| form | Liquid |
| pka | 10.58±0.46(Predicted) |
| Specific Gravity | 1.01 |
| color | Clear colorless to pale yellow |
| BRN | 970270 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 4949-44-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethyl propionylacetate(4949-44-4) |
Safety information for Ethyl propionylacetate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H227:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P370+P378:In case of fire: Use … for extinction. P405:Store locked up. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..… |
Computed Descriptors for Ethyl propionylacetate
| InChIKey | UDRCONFHWYGWFI-UHFFFAOYSA-N |
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