Ethyl chlorooxoacetate

Synonym(s):Ethyl chloroglyoxylate;Monoethyl oxalyl chloride;mono-Ethyl oxalyl chloride;Oxalic acid monoethyl ester chloride

CAS NO.：4755-77-5
Empirical Formula: C4H5ClO3
Molecular Weight: 136.53
MDL number: MFCD00000706
EINECS: 225-285-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-17 21:30:02

What is Ethyl chlorooxoacetate?

Description

Ethyl chlorooxoacetate has been used as a reactant in the preparation of oxyoxalamide derivatives as epoxide hydrolase inhibitors.

Chemical properties

clear liquid

The Uses of Ethyl chlorooxoacetate

Ethyl oxalyl chloride is used in the synthesis of 2-oxo-3-alkenoic esters and alpha-keto ester in good yield. It acts as a reactant in the preparation of oxyoxalamide derivatives as an epoxide hydrolase inhibitor.

The Uses of Ethyl chlorooxoacetate

Ethyl chlorooxoacetate can be used for the synthesis of:

α-keto esters.
Functionalized 3-pyrolin-2-ones.
Substituted arylglyoxylic acids via Friedel–Crafts acylation.
Substituted 9,10-phenanthrenequinones.
Quinoxalinone derivatives.

Properties of Ethyl chlorooxoacetate

Melting point:	156-158 °C(Solv: ethanol (64-17-5))
Boiling point:	135 °C
Density	1.222 g/mL at 25 °C(lit.)
refractive index	1.416-1.418
Flash point:	41 °C
storage temp.	Inert atmosphere,2-8°C
solubility	soluble in Chloroform
form	Liquid
Specific Gravity	1.222
color	Clear
Water Solubility	Slightly miscible with water.
Sensitive	Moisture Sensitive
BRN	506725
CAS DataBase Reference	4755-77-5(CAS DataBase Reference)
NIST Chemistry Reference	Chlorooxalic acid, ethyl ester(4755-77-5)
EPA Substance Registry System	Acetic acid, chlorooxo-, ethyl ester (4755-77-5)

Safety information for Ethyl chlorooxoacetate

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H226:Flammable liquids H314:Skin corrosion/irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.