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HomeProduct name listEthyl malonyl chloride

Ethyl malonyl chloride

Synonym(s):Ethyl (chloroformyl)acetate;Ethyl 3-chloro-3-oxopropionate

  • CAS NO.:36239-09-5
  • Empirical Formula: C5H7ClO3
  • Molecular Weight: 150.56
  • MDL number: MFCD00000736
  • EINECS: 252-934-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-15 10:43:43
Ethyl malonyl chloride Structural

What is Ethyl malonyl chloride?

Chemical properties

clear yellow to brown liquid

The Uses of Ethyl malonyl chloride

Ethyl malonyl chloride is used in the syntheses of methanofullerodendimers and 3-pyrrolin-2-ones. It plays a vital role in the preparation of 3,5-disubstituted 1,2,4-oxadiazole derivatives, which are potential peptidomimetic building blocks. It is a versatile acylating agent for propargyl alcohols, hydrazines and amines.

The Uses of Ethyl malonyl chloride

Employed in the synthesis of 3-pyrrolin-2-ones via amidation with propargylamines and subsequent base catalyzed 5-exo-dig cyclization.1

General Description

Ethyl malonyl chloride is a versatile acylating agent for propargyl alcohols, hydrazines and amines.

Properties of Ethyl malonyl chloride

Boiling point: 79-80 °C25 mm Hg(lit.)
Density  1.196 g/mL at 20 °C
refractive index  n20/D 1.429(lit.)
Flash point: 154 °F
storage temp.  2-8°C
solubility  Chloroform (Soluble), DMSO (Sparingly), Ethyl Acetate (Slightly)
pka 9.35±0.46(Predicted)
form  Liquid
color  Clear yellow to brown
Specific Gravity 1.176
Water Solubility  REACTS
Sensitive  Moisture Sensitive
BRN  636215
Stability: Hygroscopic, Moisture Sensitive
CAS DataBase Reference 36239-09-5(CAS DataBase Reference)
NIST Chemistry Reference Ethyl malonyl chloride(36239-09-5)

Safety information for Ethyl malonyl chloride

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H314:Skin corrosion/irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P363:Wash contaminated clothing before reuse.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

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