Ethyl malonyl chloride
Synonym(s):Ethyl (chloroformyl)acetate;Ethyl 3-chloro-3-oxopropionate
- CAS NO.：36239-09-5
- Empirical Formula: C5H7ClO3
- Molecular Weight: 150.56
- MDL number: MFCD00000736
- EINECS: 252-934-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:43
What is Ethyl malonyl chloride?
Chemical properties
clear yellow to brown liquid
The Uses of Ethyl malonyl chloride
Ethyl malonyl chloride is used in the syntheses of methanofullerodendimers and 3-pyrrolin-2-ones. It plays a vital role in the preparation of 3,5-disubstituted 1,2,4-oxadiazole derivatives, which are potential peptidomimetic building blocks. It is a versatile acylating agent for propargyl alcohols, hydrazines and amines.
The Uses of Ethyl malonyl chloride
Employed in the synthesis of 3-pyrrolin-2-ones via amidation with propargylamines and subsequent base catalyzed 5-exo-dig cyclization.1
General Description
Ethyl malonyl chloride is a versatile acylating agent for propargyl alcohols, hydrazines and amines.
Properties of Ethyl malonyl chloride
| Boiling point: | 79-80 °C25 mm Hg(lit.) |
| Density | 1.196 g/mL at 20 °C |
| refractive index | n |
| Flash point: | 154 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Soluble), DMSO (Sparingly), Ethyl Acetate (Slightly) |
| pka | 9.35±0.46(Predicted) |
| form | Liquid |
| color | Clear yellow to brown |
| Specific Gravity | 1.176 |
| Water Solubility | REACTS |
| Sensitive | Moisture Sensitive |
| BRN | 636215 |
| Stability: | Hygroscopic, Moisture Sensitive |
| CAS DataBase Reference | 36239-09-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethyl malonyl chloride(36239-09-5) |
Safety information for Ethyl malonyl chloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Ethyl malonyl chloride
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