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HomeProduct name listEthyl Biscoumacetate

Ethyl Biscoumacetate

  • CAS NO.:548-00-5
  • Empirical Formula: C22H16O8
  • Molecular Weight: 408.36
  • MDL number: MFCD00128073
  • EINECS: 208-940-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-04-23 13:52:06
Ethyl Biscoumacetate Structural

What is Ethyl Biscoumacetate?

Chemical properties

White, crystalline solid; odorless; bitter taste.Soluble in acetone and benzene; slightly soluble in alcohol and ether; insoluble in water.

Originator

Tromexan,Geigy,US,1950

The Uses of Ethyl Biscoumacetate

Medicine (anticoagulant).

The Uses of Ethyl Biscoumacetate

Anticoagulant.

What are the applications of Application

Ethyl Biscoumacetate is a coumarin used as an anticoagulant

Definition

A synthetic derivative of bishydroxycoumarin.

Manufacturing Process

7 g of benzotetronic acid are dissolved in 750 cc of water at boiling temperature and there after 10.5 g of glyoxylic acid ethyl ester ethyl alcoholate are added. After a short while the liquid becomes turbid and gradually a white deposit is separated. The deposit is filtrated and dried in vacuo. The melting point is 172°C to 174°C; after recrystallization from methyl alcohol 153°C to 154°C.
The crude product is dissolved in sodium lye, filtrated by means of animal charcoal precipitated by means of hydrochloric acid, and recrystallized from methyl alcohol. The melting point is 153°C to 154°C.

Therapeutic Function

Anticoagulant

Synthesis

Ethyl biscoumacetate, the ethyl ester of bis-(4-hydroxy- 3-coumarinyl)-acetic acid (24.1.9), is synthesized analogously from 4-hydroxycoumarine, but using ethylglyoxylate, its semiacetal or glyoxylic acid instead of formaldehyde.

Synthesis_548-00-5

Properties of Ethyl Biscoumacetate

Melting point: 177-182° and mp 154-157°
Boiling point: 448.92°C (rough estimate)
Density  1.3259 (rough estimate)
refractive index  1.4480 (estimate)
storage temp.  Amber Vial, -20°C Freezer, Under inert atmosphere
solubility  Chloroform (Slightly), DMSO (Slightly)
form  Solid
pka pKa 7.5 (Uncertain)
color  White
Water Solubility  54.31mg/L(temperature not stated)

Safety information for Ethyl Biscoumacetate

Computed Descriptors for Ethyl Biscoumacetate

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